{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:12:30Z","timestamp":1791357150363,"version":"4.3.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objectives:<\/i> To study the efficacy and safety of olanzapine for the treatment of children with autism associated with disruptive behavior problems. <i>Subjects and Methods:<\/i> A prospective open-label trial was conducted on 40 male children (mean age 12.2 \u00b1 2.2 years, range 7\u201317 years) meeting Diagnostic Statistical Manual IV criteria for autism. After a washout period from previous medications (2\u201314 days), patients received olanzapine (5\u201310 mg\/day) for a 13-week treatment period. The primary efficacy measures were Aberrant Behavior Checklist (ABC) and Clinical Global Impressions-Severity (CGI-S) done at baseline and end of treatment. At the beginning and end of treatment, patients underwent laboratory and physical investigations: ECG, chest X-ray, urinalysis, serum chemistry, blood glucose and lipid profile, hematology and hepatitis B serology. <i>Results:<\/i> Paired comparison of baseline and 13-week endpoint scores showed significant reductions in ABC subscale scores for irritability (p < 0.0001), lethargy (p < 0.0001), stereotyped behavior (p < 0.005), hyperactivity (p < 0.0001) and inappropriate speech (p < 0.005). Of 40 patients, 12 (30%) were considered as \u2018improved\u2019 on CGI-S scores compared to baseline, a statistically significant difference (p < 0.05). No liver enzyme elevation or any other serum biochemical changes resulted from treatment, which was not associated with significant body weight changes or any other treatment-emergent side effects. <i>Conclusions:<\/i> The study shows that olanzapine treatment can be beneficial in alleviating some behavioral symptoms (irritability, hyperactivity\/noncompliance and lethargy\/withdrawal) associated with autism. The short period of this trial limits inferences about adverse effects such as body weight increase and tardive dyskinesia. Further long-term placebo-controlled studies of olanzapine are required.<\/jats:p>","DOI":"10.1159\/000141508","type":"journal-article","created":{"date-parts":[[2008,8,8]],"date-time":"2008-08-08T13:24:45Z","timestamp":1218201885000},"page":"415-418","source":"Crossref","is-referenced-by-count":44,"title":["Olanzapine in the Treatment of Behavioral Problems Associated with Autism: An Open-Label Trial in Kuwait"],"prefix":"10.1159","volume":"17","author":[{"given":"Abdullahi","family":"Fido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Al-Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1025054610557"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1017%2FS0033291700028099"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017%2FS1462399407000452"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177%2F1362361399003001005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.02.026"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177%2F1362361305053255"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pediatrneurol.2006.11.004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080%2F15287390601172080"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1020593922901"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1901%2Fjaba.2007.63-05"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1901%2Fjaba.2007.41-06"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fhrp%2F8.2.45"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.spen.2004.07.006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00004583-200202000-00007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa013171"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10803-006-0234-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00004714-199902000-00008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00004583-200108000-00009"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F00004714-200210000-00003"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.154.5.672"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1089%2Fcap.2006.16.541"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/141508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/141508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:51:20Z","timestamp":1745459480000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000141508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000141508","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}