{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:50:23Z","timestamp":1780480223285,"version":"3.54.1"},"reference-count":6,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; To describe a patient who was misdiagnosed as having a nonfunctional pituitary tumor due to the hook effect on prolactin measurements. &lt;i&gt;Clinical Presentation and Intervention:&lt;\/i&gt; A 45-year-old female was admitted with visual disturbances, panhypopituitarism and central diabetes insipidus due to pituitary tumor recurrence. She had been operated 4 times earlier and received cranial irradiation for a suspected nonfunctional pituitary adenoma. Serum prolactin was moderately elevated (164.5 ng\/ml), but increased markedly after 1:100 dilution to 14,640 ng\/ml. Diagnosis of a giant macroprolactinoma was made and cabergoline was started. Prolactin level normalized and a mild shrinkage of the tumor was achieved after 12 months of therapy. &lt;i&gt;Conclusion:&lt;\/i&gt; The hook effect must be kept in mind while evaluating a giant pituitary adenoma with moderately elevated prolactin levels. This way unnecessary surgical procedures or irradiation may be avoided.<\/jats:p>","DOI":"10.1159\/000141512","type":"journal-article","created":{"date-parts":[[2008,8,8]],"date-time":"2008-08-08T13:24:45Z","timestamp":1218201885000},"page":"429-431","source":"Crossref","is-referenced-by-count":13,"title":["Misdiagnosis due to the Hook Effect in Prolactin Assay"],"prefix":"10.1159","volume":"17","author":[{"given":"Serkan","family":"Yener","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"Comlekci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Arda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman","family":"Men","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Yesil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2006.02562.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1025334001748"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-199804000-00126"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.1996.t01-1-00826.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11060-005-9108-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.1996.663486.x"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/141512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/141512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:51:24Z","timestamp":1745459484000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000141512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":6,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000141512","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}