{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:19:52Z","timestamp":1791537592952,"version":"4.3.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>We determined the roles of platelet-activating factor (PAF) and histamine in anaphylactic hypotension in ovalbumin-sensitized anesthetized BALB\/c mice. The effects of PAF and histamine on hemodynamic variables were studied by measuring the systemic arterial (Psa), portal venous (Ppv) and central venous (Pcv) pressures. Intravenous PAF evoked a biphasic Psa response, an initial rapid and transient drop followed by marked hypotension, accompanied by a decrease in Pcv. Histamine caused only mild systemic hypotension. Both agents similarly increased Ppv by approximately 4 cm H&lt;sub&gt;2&lt;\/sub&gt;O at high doses. After an injection of antigen, Psa initially increased slightly and then decreased from the baseline of 94 \u00b1 1 mm Hg to 46 \u00b1 1 mm Hg at 10 min after antigen administration, with Pcv decreasing by 2.5 cm H&lt;sub&gt;2&lt;\/sub&gt;O. Ppv increased by 3.5 cm H&lt;sub&gt;2&lt;\/sub&gt;O at 5 min after antigen injection. Pretreatment with either CV-6209 (PAF receptor antagonist, 1 mg\/kg) or diphenhydramine (histamine H&lt;sub&gt;1&lt;\/sub&gt; receptor antagonist, 20 mg\/kg) significantly attenuated an antigen-induced decrease in Psa. The inhibitory action of CV-6209 was greater than that of diphenhydramine, and the combination of these 2 antagonists almost completely inhibited the anaphylactic hypotension. In contrast, the antigen-induced increase in Ppv was attenuated by CV-6209 alone but augmented by diphenhydramine. It is concluded that anaphylactic hypotension is mainly mediated by PAF and, to a lesser extent, by histamine in anesthetized BALB\/c mice.<\/jats:p>","DOI":"10.1159\/000141516","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T12:07:27Z","timestamp":1214482047000},"page":"114-120","source":"Crossref","is-referenced-by-count":33,"title":["PAF, rather than Histamine, Participates in Mouse Anaphylactic Hypotension"],"prefix":"10.1159","volume":"82","author":[{"given":"Toshishige","family":"Shibamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Kurata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.12.1125"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.123302"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.187.11.1779"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpheart.00368.2005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2170%2Fjjphysiol.S642"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Fpupt.2000.0318"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.plefa.2006.12.007"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/141516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/141516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:51:27Z","timestamp":1745459487000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000141516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000141516","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}