{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:26:20Z","timestamp":1770434780224,"version":"3.49.0"},"reference-count":9,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Idiopathic CD4+ lymphocytopenia is a rare disease without HIV infection or any other underlying immunodeficiency. Patients with this condition are predisposed to various opportunistic infections. We describe a 31-year-old woman with giant molluscum contagiosum disseminated over nearly the whole body. Immunologic analysis disclosed very low numbers of CD4+ lymphocytes (&lt;11\/\u00b5l, normal range: 240\u20133,100), an abnormal proliferative response of the patient\u2019s lymphocytes to artificial mitogens and specific antigens, and an anergic delayed-type hypersensitivity skin response. HIV serology was repetitively negative. The diagnosis of idiopathic CD4+ lymphocytopenia was established. Systemic treatment with pegylated interferon-\u03b12b (50 \u00b5g\/week) for 16 months resulted in complete eradication of her disseminated giant molluscum contagiosum. In this report we will further describe the nature of idiopathic CD4+ lymphocytopenia and emphasize its relevance to clinical dermatology.<\/jats:p>","DOI":"10.1159\/000141649","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T12:07:27Z","timestamp":1214482047000},"page":"196-198","source":"Crossref","is-referenced-by-count":15,"title":["Disseminated Giant Molluscum Contagiosum in a Patient with Idiopathic CD4+ Lymphocytopenia"],"prefix":"10.1159","volume":"217","author":[{"given":"Markus","family":"B\u00f6hm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Luger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Bonsmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F01.bor.0000231908.57913.2f"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2Fmd.0b013e31803b52f5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1995.tb02717.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.80.1.77"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-2706"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fintimm%2F12.4.449"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118464"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1086%2F425121"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-06-031385"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/141649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/141649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:53:17Z","timestamp":1745459597000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000141649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000141649","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}