{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:06:09Z","timestamp":1790438769311,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Adequate peri-operative analgesia may reduce post-operative stress response and improve recovery in laboratory animals. We have established a method involving repeated automated blood sampling, allowing quantification of serum corticosterone levels in rats for stress assessment without stress-inducing handling or restraint. In the present study, the effects of the commonly used route of buprenorphine administration (0.05 mg\/kg injected subcutaneously) were compared with oral administration (0.4 mg\/kg mixed with Nutella\u00ae and orally administered by voluntary ingestion) in male Sprague-Dawley rats. <i>Methods:<\/i> A catheter was placed in the jugular vein and attached to an Accusampler\u00ae for automated blood sampling. During 96 h after surgery, blood was collected at specified time points. Pre- and post-operative body weights and water consumption were registered. <i>Results:<\/i> Buprenorphine significantly suppressed levels of circulating corticosterone after the oral but not after the subcutaneous treatment. Both buprenorphine treatments had a positive impact on maintenance of body weight and water consumption, compared to the control group that received no buprenorphine. <i>Conclusion:<\/i> The present investigation suggests that oral voluntary ingestion ad libitum is an efficacious, convenient and non-invasive way of administering peri-operative buprenorphine to rats, as judged by corticosteroid response and effects on body weight and water consumption.<\/jats:p>","DOI":"10.1159\/000142372","type":"journal-article","created":{"date-parts":[[2008,7,3]],"date-time":"2008-07-03T06:06:24Z","timestamp":1215065184000},"page":"272-278","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Subcutaneous Injection and Oral Voluntary Ingestion of Buprenorphine on Post-Operative Serum Corticosterone Levels in Male Rats"],"prefix":"10.1159","volume":"41","author":[{"given":"R.","family":"Goldkuhl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-E.","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.P.","family":"Abelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fbja%2F85.1.109"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006%2Fjsre.1999.5789"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2005.04.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-3057%2879%2990102-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-200018120-00020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0684.2000.290505.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0889-1591%2887%2990002-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2892%2990475-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1258%2F002367784780891226"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2888%2990543-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2896%2901069-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1258%2F0023677011911651"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1258%2F002367702320162423"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1258%2F002367799780578381"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1258%2F002367798780600025"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.0.1800145"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000026437"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2885%2990002-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0162-3109%2800%2900198-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbi.2007.01.001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2826.2006.01444.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.npp.1300201"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.npp.1300016"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1258%2F002367792780740558"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/142372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/142372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:10:56Z","timestamp":1745457056000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000142372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000142372","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}