{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:20:06Z","timestamp":1770434406702,"version":"3.49.0"},"reference-count":7,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Copaxone (glatiramer acetate) is a synthetic copolymer mimicking a portion of myelin basic protein, one of several putative autoantigens in multiple sclerosis (MS). Copaxone suppresses the production of tumor necrosis factor (TNF)-\u03b1, a key mediator of inflammation in MS as well as in other pathologies, such as colitis of interstitial bowel disease (IBD). Copaxone is a drug approved for the treatment of MS, and one that is very well tolerated with a high safety profile and relatively few side effects. Crohn\u2019s disease has not been associated with its administration. &lt;i&gt;Methods:&lt;\/i&gt; We describe a patient with MS in remission who had not exhibited any signs of IBD in the past. She had been on Copaxone 20 mg\/day treatment for 2 years when she first exhibited gastrointestinal symptoms. &lt;i&gt;Results:&lt;\/i&gt; Our patient developed Crohn\u2019s disease while on Copaxone treatment as a consequence of long-term immunosuppression. &lt;i&gt;Conclusions:&lt;\/i&gt; Clinicians should be aware that Crohn\u2019s disease is a potential &lt;i&gt;novel&lt;\/i&gt; adverse drug effect of Copaxone.<\/jats:p>","DOI":"10.1159\/000143156","type":"journal-article","created":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T05:20:14Z","timestamp":1215494414000},"page":"198-200","source":"Crossref","is-referenced-by-count":11,"title":["Development of Crohn\u2019s Disease in a Patient with Multiple Sclerosis Treated with Copaxone"],"prefix":"10.1159","volume":"77","author":[{"given":"Gideon","family":"Charach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itamar","family":"Grosskopf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2807%2970132-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1517%2F14656566.2.7.1149"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00054725-200502000-00003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2001.22122"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2960750-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clim.2005.10.004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003840000227"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/143156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/143156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:18:41Z","timestamp":1745457521000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000143156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":7,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000143156","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}