{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:01:53Z","timestamp":1784091713111,"version":"3.55.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> The issue of whether 21% O<sub>2<\/sub> is more effective than 100% O<sub>2<\/sub> for resuscitation of newborn infants remains controversial. <i>Objectives:<\/i> We have updated the systematic review and meta-analysis including all studies reporting resuscitation of newborn infants with 21 or 100% O<sub>2<\/sub>. <i>Methods:<\/i> Randomized or quasi-randomized studies of depressed newborn infants resuscitated with 21 or 100% O<sub>2<\/sub> with or without masking of treatment were considered for inclusion. The outcomes of interest included neonatal mortality and hypoxic ischemic encephalopathy. <i>Results:<\/i> Ten studies fulfilled the inclusion criteria. Of these, 6 studies were identified as being strictly randomized. In total, 1,082 infants were allocated to resuscitation with 21% O<sub>2<\/sub> and 1,051 infants with 100% O<sub>2<\/sub>. The risk of neonatal mortality was reduced in the 21% O<sub>2<\/sub> group compared to the 100% O<sub>2 <\/sub>group both in the analysis of all studies (typical RR 0.69, 95% CI 0.54, 0.88) and in the analysis of strictly randomized studies (typical RR 0.32, 95% CI 0.12, 0.84). A trend toward a decrease in the risk of hypoxic ischemic encephalopathy stage 2 and 3 was noted with resuscitation in 21% O<sub>2<\/sub> in the analysis of all studies (typical RR 0.88, 95% CI 0.72, 1.08). <i>Conclusions:<\/i> There is a significant reduction in the risk of neonatal mortality and a trend towards a reduction in the risk of severe hypoxic ischemic encephalopathy in newborns resuscitated with 21% O<sub>2<\/sub>.<\/jats:p>","DOI":"10.1159\/000143397","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T06:15:55Z","timestamp":1215670555000},"page":"176-182","source":"Crossref","is-referenced-by-count":276,"title":["Resuscitation of Newborn Infants with 21% or 100% Oxygen: An Updated Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"94","author":[{"given":"Ola Didrik","family":"Saugstad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddarth","family":"Ramji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger F.","family":"Soll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximo","family":"Vento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000101349"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000080950"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2917189-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.resuscitation.2006.06.134"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199312000-00023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.102.1.e1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000047103"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2003.252"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-0206"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200412-1740OC"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Ftropej%2Ffmh086"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-2456%2895%2900134-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.2.296"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250216105"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.03.008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.04.058"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250510036507"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-0832"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-0102"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2007-1984"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/143397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/143397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:21:23Z","timestamp":1745457683000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000143397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000143397","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}