{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:54:58Z","timestamp":1745470498460,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1976,1,1]],"date-time":"1976-01-01T00:00:00Z","timestamp":189302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1976,1,1]],"date-time":"1976-01-01T00:00:00Z","timestamp":189302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells Tissues Organs"],"published-print":{"date-parts":[[1976]]},"abstract":"<jats:p>The effects of the long-acting prostaglandin A&lt;sub&gt;x&lt;\/sub&gt; upon pregnancy and fetal development were investigated in Long-Evans rats. The animals were treated by the intra-uterine route either on gestational day 14 with 25 &lt;i&gt;\u03bc&lt;\/i&gt;g PGA&lt;sub&gt;1&lt;\/sub&gt; or with 50 &lt;i&gt;\u03bc&lt;\/i&gt;g on day 17 of gestation. The incidence of fetal resorptions was significantly increased compared to the controls following treatment on gestational day 17. A significantly high incidence of nonspecific malformations was also induced in the offspring as a result of the treatment. There were no significant differences between experimental and control fetal and placental weights. The total protein content of fetal liver following treatment with PGA&lt;sub&gt;1&lt;\/sub&gt; was not significantly reduced. Microscopic examination of placentas showed a consistent decrease in the thickness of the decidua basalis following treatment with 25 &lt;i&gt;\u03bc&lt;\/i&gt;g PGA&lt;sub&gt;1&lt;\/sub&gt; on day 14 of gestation. The ovaries and umbilical cords showed no changes. In addition, treatment of rats daily with 200 &lt;i&gt;\u03bc&lt;\/i&gt;g PGA&lt;sub&gt;1&lt;\/sub&gt;, administered subcutaneously, on gestational days 9\u201312 or 12\u201315 did not affect the development of the conceptuses.<\/jats:p>","DOI":"10.1159\/000144600","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T12:22:21Z","timestamp":1235737341000},"page":"40-49","source":"Crossref","is-referenced-by-count":2,"title":["Pregnancy and progeny in rats treated with prostaglandin A&lt;sub&gt;1&lt;\/sub&gt;"],"prefix":"10.1159","volume":"95","author":[{"given":"C.W.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.V.N.","family":"Persaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,7,9]]},"container-title":["Cells Tissues Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/144600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/144600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:34:59Z","timestamp":1745458499000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000144600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000144600","archive":["Portico"],"relation":{},"ISSN":["1422-6405","1422-6421"],"issn-type":[{"type":"print","value":"1422-6405"},{"type":"electronic","value":"1422-6421"}],"subject":[],"published":{"date-parts":[[1976]]}}}