{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:55:18Z","timestamp":1745470518951,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1980,1,1]],"date-time":"1980-01-01T00:00:00Z","timestamp":315532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1980,1,1]],"date-time":"1980-01-01T00:00:00Z","timestamp":315532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells Tissues Organs"],"published-print":{"date-parts":[[1980]]},"abstract":"<jats:p>An attempt was made to study the effects of cyproterone acetate (CA), an antiandrogen, on the testicular activity of the frog &lt;i&gt;Rana temporaria, &lt;\/i&gt;employing histological and histochemical methods. Each treated frog received a total dose of 4 mg during the period of 4 weeks. Light-microscopic examinations revealed that CA blocked the formation of spermatids and mature sperms; however, the early stages of spermatogenesis, i.e. proliferation and development of spermatogonia and spermatocytes, remained unaffected. CA caused interstitial tissue disruption and degeneration, and led to the shrinkage of Leydig cells; the drug stopped the production of lipoidal material in the interstitial tissues. Also, a loss of testicular weight was documented in the frogs treated with CA.<\/jats:p>","DOI":"10.1159\/000145204","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T12:22:21Z","timestamp":1235737341000},"page":"387-391","source":"Crossref","is-referenced-by-count":4,"title":["Histophysiological effects of an antiandrogen (cyproterone acetate) on the testis of the frog &lt;i&gt;Rana temporaria&lt;\/i&gt;"],"prefix":"10.1159","volume":"106","author":[{"given":"Sye G.","family":"Haider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,7,9]]},"container-title":["Cells Tissues Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/145204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/145204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:41:03Z","timestamp":1745458863000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000145204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000145204","archive":["Portico"],"relation":{},"ISSN":["1422-6405","1422-6421"],"issn-type":[{"type":"print","value":"1422-6405"},{"type":"electronic","value":"1422-6421"}],"subject":[],"published":{"date-parts":[[1980]]}}}