{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:24:14Z","timestamp":1760783054787,"version":"3.40.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T00:00:00Z","timestamp":1216944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T00:00:00Z","timestamp":1216944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; To examine whether treatment of secondary hyperparathyroidism with paricalcitol provides benefits to arteries in uremic rats. &lt;i&gt;Methods:&lt;\/i&gt; 5\/6-nephrectomized rats were treated (NX+Pari) or not treated (NX) with paricalcitol (200 ng\/kg, thrice weekly) for 12 weeks. Aortic histology and isolated segments of the main and 2nd-order mesenteric arterial branches were studied. &lt;i&gt;Results:&lt;\/i&gt; Creatinine clearance was reduced by 54\u201361%, plasma phosphate increased 2.1- to 2.5-fold, and blood pressure by 40 mm Hg in both NX groups. PTH increased 13-fold in NX and 5-fold in NX+Pari rats. Calcification in aortic cross-sections increased from 2.1 to 7.1% after paricalcitol. In the large mesenteric artery, vasoconstriction to noradrenaline was reduced in NX+Pari rats. In the large and small arteries, vasorelaxation to acetylcholine was impaired in NX rats and unaffected by paricalcitol. In the small artery, paricalcitol increased nitric oxide synthase inhibition-resistant relaxation to acetylcholine, and maximal relaxation to levcromakalim. The small arteries of NX rats featured increased wall cross-sectional area, while paricalcitol further increased wall thickness and the wall:lumen ratio. &lt;i&gt;Conclusion:&lt;\/i&gt; Paricalcitol treatment showed both benefits and harmful effects in uremic rats: in the large artery vasoconstriction was reduced but calcification increased, while in the small artery vasorelaxation via potassium channels was moderately improved but hypertrophic remodeling was aggravated.<\/jats:p>","DOI":"10.1159\/000145464","type":"journal-article","created":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T11:53:26Z","timestamp":1216986806000},"page":"e84-e93","source":"Crossref","is-referenced-by-count":16,"title":["Paricalcitol Treatment and Arterial Tone in Experimental Renal 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