{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:29:45Z","timestamp":1791174585329,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Prognostic studies of T-cell lymphoblastic leukemia\/lymphoma (T-ALL) have been performed in small patient cohorts with conflicting results. We systematically reviewed 67 adult T-ALL patients diagnosed and treated at our institute to identify clinical and pathologic prognostic factors. The median initial WBC was 21.3 \u00d7 10&lt;sup&gt;9&lt;\/sup&gt;\/l. Blasts expressed at least one myeloid-associated antigen in 33%. Karyotypes were abnormal in 32% of the cases. Fifty-six of 64 patients (88%) achieved complete remission (CR). In univariate analysis, age, gender, initial WBC, CD10, CD34 and abnormal karyotype did not predict CR. Patients expressing at least one myeloid-associated antigen had a CR of 74% compared to 94% (p = 0.04) for those not expressing myeloid antigens. None of the above factors affected relapse-free or overall survival in this cohort. Our study indicates that expression of myeloid-associated antigens is associated with a lower CR rate in adult T-ALL and may be considered in risk stratification for induction chemotherapy.<\/jats:p>","DOI":"10.1159\/000146081","type":"journal-article","created":{"date-parts":[[2008,7,21]],"date-time":"2008-07-21T13:56:06Z","timestamp":1216648566000},"page":"5-10","source":"Crossref","is-referenced-by-count":14,"title":["Adult Precursor T-Lymphoblastic Leukemia\/Lymphoma with Myeloid-Associated Antigen Expression Is Associated with a Lower Complete Remission Rate following Induction Chemotherapy"],"prefix":"10.1159","volume":"120","author":[{"given":"Murtadha","family":"AL Khabori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Samiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Brandwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,7,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.02.053"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2402526"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.leukres.2006.08.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-04-1754"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2004-09-3666"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109%2F10428199109068052"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-04-1623"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0145-2126%2803%2900180-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-01-0110"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V99.3.863"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra052603"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.20668"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0889-8588%2805%2970190-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj%2Fleu%2F2401555"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-10-051912"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109%2F10428199609093444"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/146081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/146081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:43:54Z","timestamp":1745455434000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000146081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000146081","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}