{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:53:06Z","timestamp":1745470386555,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells Tissues Organs"],"published-print":{"date-parts":[[1992]]},"abstract":"<jats:p>The immunohistochemical localization of proteins G&lt;sub&gt;i1&lt;\/sub&gt; (plus G&lt;sub&gt;i3&lt;\/sub&gt;). G&lt;sub&gt;i2&lt;\/sub&gt; and G&lt;sub&gt;o&lt;\/sub&gt; was studied in the olfactory epithelium and the main olfactory bulb of rats, using purified antibodies to the respective \u03b1 subunits and \u03b2\u03b3 subunits of these G proteins. In the olfactory epithelium, only a restricted population of olfactory cells was immunopositive for G&lt;sub&gt;i2&lt;\/sub&gt;\u03b1, but others were not. The immunoreactivity for G&lt;sub&gt;i1&lt;\/sub&gt;\u03b1\/G&lt;sub&gt;i3&lt;\/sub&gt;\u03b1 was not observed. The olfactory epithelium was immunopositive for both G&lt;sub&gt;o&lt;\/sub&gt;\u03b1 and \u03b2\u03b3, but its apical surface was immunopositive only for \u03b2\u03b3. In the main olfactory bulb, all layers were intensely immunopositive for G&lt;sub&gt;o&lt;\/sub&gt;\u03b1 and \u03b2\u03b3 but weakly for G&lt;sub&gt;i2&lt;\/sub&gt;\u03b1. In contrast to the negative or weak immunostainings in the olfactory nerve fiber layer and glomeruli, the molecular and the internal granular layers were intensely immunopositive for G&lt;sub&gt;i1&lt;\/sub&gt;\u03b1\/G&lt;sub&gt;i3&lt;\/sub&gt;\u03b1. These findings suggest the functional difference among G&lt;sub&gt;i1&lt;\/sub&gt;\u03b1\/G&lt;sub&gt;i3&lt;\/sub&gt;, G&lt;sub&gt;i2&lt;\/sub&gt; and G&lt;sub&gt;o&lt;\/sub&gt; in the signal transduction in the olfactory system.<\/jats:p>","DOI":"10.1159\/000147301","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T14:22:56Z","timestamp":1216390976000},"page":"167-171","source":"Crossref","is-referenced-by-count":19,"title":["Differential Localization of G Proteins, G, and G&lt;sub&gt;o&lt;\/sub&gt;, in the Olfactory Epithelium and the Main Olfactory Bulb of the Rat"],"prefix":"10.1159","volume":"144","author":[{"given":"H.","family":"Shinohara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,7,16]]},"container-title":["Cells Tissues Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/147301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/147301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:57:18Z","timestamp":1745456238000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000147301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000147301","archive":["Portico"],"relation":{},"ISSN":["1422-6405","1422-6421"],"issn-type":[{"type":"print","value":"1422-6405"},{"type":"electronic","value":"1422-6421"}],"subject":[],"published":{"date-parts":[[1992]]}}}