{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:53:08Z","timestamp":1745470388831,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells Tissues Organs"],"published-print":{"date-parts":[[1992]]},"abstract":"<jats:p>This paper studies the influence of an antimitotic factor (puromycin) and a hormonal factor (thyroid hormone, TH) on canal growth. The tibiae of 15 six-day-old rats were cultured in a serum-free chemically defined medium. The cultures were carried out for as long as 6 days. Our results show: (1) canal growth is not dependent on perichondrium or chondroepiphysis growth; (2) the canal is greater and has a complex pattern in a triiodothyronine (T&lt;sub&gt;3&lt;\/sub&gt;)-treated assay group; (3) round and multinucleated cells are more numerous in the T&lt;sub&gt;3&lt;\/sub&gt;-treated assay group than in the other groups. We hypothesize that the canal grows by a physiological phenomenon of programed cell death and that it is stimulated by TH.<\/jats:p>","DOI":"10.1159\/000147356","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T14:22:56Z","timestamp":1216390976000},"page":"143-148","source":"Crossref","is-referenced-by-count":6,"title":["Cartilage Canal Growth: Experimental Approach in the Rat Tibia"],"prefix":"10.1159","volume":"145","author":[{"given":"E.","family":"Delgado-Baeza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nieto-Chaguaceda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Miralles-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Santos-Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,7,16]]},"container-title":["Cells Tissues Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/147356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/147356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:57:46Z","timestamp":1745456266000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000147356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000147356","archive":["Portico"],"relation":{},"ISSN":["1422-6405","1422-6421"],"issn-type":[{"type":"print","value":"1422-6405"},{"type":"electronic","value":"1422-6421"}],"subject":[],"published":{"date-parts":[[1992]]}}}