{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:19:14Z","timestamp":1759342754220},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>In an attempt to assess the level of quinolone resistance and its association with other antimicrobial resistance in faecal &lt;i&gt;Escherichia coli&lt;\/i&gt; isolated from routine outpatient specimens in Hong Kong, ciprofloxacin-supplemented MacConkey agar was used to screen for resistant isolates. Antimicrobial susceptibility testing of the isolates was done by VITEK 2 and previous amplification-based methods were employed to characterize the genetic determinants behind some of the resistance phenotypes. One hundred and seventy-six (43%) of 409 specimens had quinolone-resistant &lt;i&gt;E. coli&lt;\/i&gt; isolated (199 isolates). Quinolone resistance was found to be associated with resistances to penicillins (&gt;80%) and co-trimoxazole (69%). Nonsusceptibility to combinations of penicillins and clavulanic acid was above 20% and up to 50% for the aminoglycosides gentamicin and tobramycin. CTX-M-type extended-spectrum \u03b2-lactamases were found responsible for most cephalosporin resistances but the transferable quinolone resistance determinant &lt;i&gt;qnrA&lt;\/i&gt; was not detected. Our data suggested that a high percentage of &lt;i&gt;E. coli&lt;\/i&gt; isolates as part of the alleged normal intestinal microflora in humans appeared to be resistant to quinolones. Co-resistance to various other frequently used antimicrobials was also observed. Transferable genetic determinants were found to be involved in some cases.<\/jats:p>","DOI":"10.1159\/000149718","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T11:03:33Z","timestamp":1218539013000},"page":"274-278","source":"Crossref","is-referenced-by-count":5,"title":["Quinolone Resistance and Correlation to Other Antimicrobial Resistances in Faecal Isolates of &lt;i&gt;Escherichia coli&lt;\/i&gt; in Hong Kong"],"prefix":"10.1159","volume":"54","author":[{"given":"Yiu Wai","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence K.M.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Ho","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grand K.L.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenwai","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen S.Y.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai Man","family":"Kam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000048498"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.47.1.436-439.2003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.42.7.3321-3323.2004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000112416"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdki250"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.00548-06"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1054%2Fdrup.1998.0068"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.46.1.1-11.2002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1086%2F345880"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1086%2F322667"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1086%2F345754"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/149718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/149718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T19:35:42Z","timestamp":1726169742000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/CHE\/article\/doi\/10.1159\/000149718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000149718","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2008]]}}}