{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:00:21Z","timestamp":1792047621691,"version":"4.4.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> This is the first report testing the antibiotic resistance-modifying activity of <i>Mentha arvensis. <\/i><i>Methods:<\/i> In this study an ethanol extract of <i>M. arvensis<\/i> L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with conventional antibiotics against strains of <i>Escherichia coli<\/i>. <i>Results:<\/i> The growth of two <i>E. coli<\/i> strains tested was not inhibited by the extract. The minimum inhibitory concentration and minimal bactericide concentration values were \u22671 mg\/ml for both strains of <i>E. coli<\/i> used. A potentiating effect of this extract on gentamicin was demonstrated. Similarly, there was a potentiating effect of chlorpromazine on kanamycin, amikacin and tobramycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. <i>Conclusions:<\/i> It is therefore suggested that extracts from <i>M. arvensis<\/i> could be used as a source of plant-derived natural products with resistance-modifying activity, such as in the case of gentamicin, constituting a new weapon against bacterial resistance to antibiotics, as with chlorpromazine.<\/jats:p>","DOI":"10.1159\/000151267","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T05:41:55Z","timestamp":1218692515000},"page":"328-330","source":"Crossref","is-referenced-by-count":273,"title":["Enhancement of the Antibiotic Activity against a Multiresistant <i>Escherichia coli<\/i> by <i>Mentha arvensis <\/i>L. and Chlorpromazine"],"prefix":"10.1159","volume":"54","author":[{"given":"Henrique D.M.","family":"Coutinho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 G.M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edeltrudes O.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivyanne S.","family":"Falc\u00e3o-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 P.","family":"Siqueira-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080%2F14786410500463395"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186%2F1472-6882-7-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fct.2007.02.031"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fitote.2006.11.010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000095960"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mam.2005.07.008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1039%2Fb212695h"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1556%2FAMicr.51.2004.3.11"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fitote.2004.12.009"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2004.11.016"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00253-005-0279-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phytochem.2006.10.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1590%2FS1516-93322006000200004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021%2Fjm9509410"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186%2F1472-6882-6-39"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2007.01.032"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fitote.2006.03.013"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000098246"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1081%2FIPH-120020475"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2F40.3.319"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.77.7.3974"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkg224"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T15:35:45Z","timestamp":1726155345000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/CHE\/article\/doi\/10.1159\/000151267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000151267","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}