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Several lines of evidence suggest that the positive feedback between keratinocytes and immunocytes plays a key role in the development of the lesions. On the other hand, little information is available on the negative regulatory controls that maintain a new homoeostasis level in psoriatic skin. We suggest here that the interplay of these two contrary feedbacks is likely to entail a hysteresis effect and that psoriasis is likely to be interpreted as a critical phenomenon characterized by a catastrophic shift of the skin from a normal to a hyperplastic state.<\/jats:p>","DOI":"10.1159\/000151354","type":"journal-article","created":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T09:47:59Z","timestamp":1218793679000},"page":"295-298","source":"Crossref","is-referenced-by-count":1,"title":["Origin of Threshold Behaviour in Psoriatic 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