{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:38:50Z","timestamp":1755034730273},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Introduction:<\/i> The effect of <i>L<\/i>-arginine on bladder tissue structure and function in a rat bladder injury model were investigated. <i>Methods:<\/i> 24 male Sprague-Dawley rats were used. The control group received a regular diet. The <i>L<\/i>-arginine group received oral <i>L<\/i>-arginine (1 g\/day). The protamine sulfate (PS) group received intravesical PS every 48 h (0.5 ml, 5 mg\/ml). <i>L<\/i>-Arginine was administered to the PS+<i>L<\/i>-arginine group in addition to PS. At the end of 1 week, bladder tissues were processed for histological and functional studies. <i>Results:<\/i> The PS group revealed urothelial damage with glycosaminoglycan layer irregularity and mast cell infiltration which was not evident in the PS+<i>L<\/i>-arginine group. 120 m<i>M<\/i> potassium and electrical field stimulation (EFS)-induced contractions in the PS group were significantly lower than in other groups, whereas carbachol-induced contractions were not significantly different. Relaxation responses of precontracted strips to EFS and isoproterenol did not reveal a significant decrease in the PS group, whereas <i>L<\/i>-arginine significantly enhanced these responses in PS-treated animals. <i>Conclusions:<\/i> Intravesical PS causes urothelial damage and inflammation that is associated with significant changes in rat bladder tissue contractility. Oral <i>L<\/i>-arginine treatment is found to prevent these histological and contractile alterations. Our findings may indicate the nitric oxide-cGMP pathway as a possible therapeutic target in various bladder diseases associated with urothelial damage.<\/jats:p>","DOI":"10.1159\/000151417","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T07:47:16Z","timestamp":1224229636000},"page":"347-352","source":"Crossref","is-referenced-by-count":3,"title":["Prophylactic Role of Oral <i>L<\/i>-Arginine on Histological and Contractile Changes in a Rat Chronic Bladder Injury Model"],"prefix":"10.1159","volume":"81","author":[{"given":"Abdurrahman","family":"\u00d6zg\u00fcr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikret Fatih","family":"\u00d6nol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feriha","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tufan","family":"Tarcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2963178-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2967208-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2898%2900343-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410x.2000.00490.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2894%2980206-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2004.04968.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1681.2002.03607.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2967587-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0703068"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2965253-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.autneu.2005.07.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fnau.20368"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0706832"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T19:46:41Z","timestamp":1715975201000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/UIN\/article\/doi\/10.1159\/000151417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000151417","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}