{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:19:31Z","timestamp":1759479571176},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Folate and cobalamin are responsible for healthy growth. However, the B-vitamin and homocysteine status of adolescents is not well known. The aim was to assess the status of folate, cobalamin, and homocysteine in healthy Spanish adolescents. &lt;i&gt;Methods:&lt;\/i&gt; Serum cobalamin, serum folate, homocysteine, methylenetetrahydrofolate reductase 677C&gt;T variant, BMI, smoking habits, and Tanner stage were determined according to gender in 165 adolescents (84 females, 81 males; 13\u201318.5 years) using the Student\u2019s t test, Mann-Whitney U test and \u03c7&lt;sup&gt;2&lt;\/sup&gt; test, respectively. Interactions between socioeconomic status, age group, methylenetetrahydrofolate reductase polymorphism, BMI, smoking habits, Tanner stage, and vitamin status, respectively, were examined by ANOVA or Kruskal-Wallis H test (p &lt; 0.05). &lt;i&gt;Results:&lt;\/i&gt; Boys had markedly higher homocysteine (males 8.92 (5.51\u201322.94) \u00b5mol\/l; females 7.91 (5.09\u201313.86) \u00b5mol\/l), whereas girls showed higher serum cobalamin concentrations (males 540.00 (268.00\u2013946.47) pmol\/l; females 594.82 (280.63\u20131,559.64) pmol\/l). Data are shown as medians and the 2.5th to 97.5th percentiles in parentheses. Adolescents with the homozygous variant of methylenetetrahydrofolate reductase displayed significantly higher homocysteine and lower serum folate: normal 5.73 (3.09\u201310.73) ng\/ml serum folate, 7.57 (4.94\u201312.94) \u00b5mol\/l homocysteine; homozygous 4.10 (2.75\u20137.88) ng\/ml serum folate, 10.83 (7.00\u201322.82) \u00b5mol\/l homocysteine. &lt;i&gt;Conclusion:&lt;\/i&gt; The present study provides data on the folate, cobalamin, and homocysteine status of Spanish adolescents. To assure a better assessment, revision of references for adolescents is still needed.<\/jats:p>","DOI":"10.1159\/000151485","type":"journal-article","created":{"date-parts":[[2008,8,20]],"date-time":"2008-08-20T10:03:01Z","timestamp":1219226581000},"page":"315-321","source":"Crossref","is-referenced-by-count":5,"title":["Methylenetetrahydrofolate Reductase 677CT Polymorphism and Cobalamin, Folate, and Homocysteine Status in Spanish Adolescents"],"prefix":"10.1159","volume":"52","author":[{"given":"Jasmin","family":"Al-Tahan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Sola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonatan R.","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Breidenassel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Garc\u00eda-Fuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Pietrzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Gonz\u00e1lez-Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,8,19]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1111%2Fj.1753-4887.1981.tb06735.x"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1046%2Fj.1365-277X.2002.00396.x"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1080%2F01635589209514201"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016%2F0098-2997%2894%2990005-1"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1515%2FCCLM.2003.218"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1177%2F000992288702601211"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1007%2Fs00392-004-0075-3"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1038%2Fng0595-111"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1093%2Fqjmed%2F90.2.111"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1001%2Fjama.288.16.2023"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1079%2FBJN20041160"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1024%2F0300-9831.70.2.48"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1159%2F000084738"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1016%2FS0899-9007%2803%2900040-6"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016%2FS0022-2836%2802%2900405-9"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1136%2Fadc.51.3.170"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1001%2Fjama.281.13.1189"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1016%2Fj.clnu.2006.02.006"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1203%2F01.pdr.0000246099.39469.18"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1038%2Fsj.ejcn.1602280"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1373%2Fclinchem.2003.019869"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1016%2FS0009-8981%2897%2906548-0"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1056%2FNEJM199905133401901"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1079%2FBJN2001479"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1016%2Fj.jadohealth.2005.03.027"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1007%2Fs007260170037"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T18:36:42Z","timestamp":1726166202000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/ANM\/article\/doi\/10.1159\/000151485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000151485","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"type":"print","value":"0250-6807"},{"type":"electronic","value":"1421-9697"}],"subject":[],"published":{"date-parts":[[2008]]}}}