{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:19:21Z","timestamp":1790882361278,"version":"4.1.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,8,25]],"date-time":"2008-08-25T00:00:00Z","timestamp":1219622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,8,25]],"date-time":"2008-08-25T00:00:00Z","timestamp":1219622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background:<\/i> End-stage renal disease (ESRD) patients are thought to have impaired 1-\u03b1-hydroxylase capacity, but an extrarenal source of 1,25(OH)<sub>2<\/sub>D has been recognized. <i>Objective:<\/i> The aim of this study was to assess the evolution of serum 1,25(OH)<sub>2<\/sub>D in hemodialysis (HD) patients with vitamin D deficiency after 6 months of 25(OH)D<sub>3<\/sub> supplementation, and to identify the factors associated with persistent 1,25(OH)<sub>2<\/sub>D production. <i>Methods:<\/i> HD patients in a HD center with vitamin D deficiency (i.e. 25(OH)D <75 nmol\/l) who were not receiving any vitamin D derivatives or calcimimetics were studied. Patients who had previously undergone parathyroidectomy or nephrectomy or those with uncontrolled hypercalcemia or hyperphosphatemia were excluded from this study. The patients were administrated a dose of 10\u201330 \u00b5g\/day of oral 25(OH)D<sub>3<\/sub> based on the severity of their deficiency. The serum levels of 25(OH)D and 1,25(OH)<sub>2<\/sub>D evolution after 6 months were recorded. Responders were defined as patients with an increase in serum 1,25(OH)<sub>2<\/sub>D levels greater than the median value. Changes in mineral metabolism parameters were compared with those in the nonresponders. <i>Results:<\/i> Of the 253 patients, 225 (89%) were vitamin D-deficient, and 43 met the inclusion criteria. The patients were 72.6 \u00b1 10 years old and had been on dialysis for 71 \u00b1 70 months; 39% of the patients were female and 45% were diabetics. From baseline to 6 months of treatment, serum 25(OH)D levels increased from 27.8 \u00b1 18 to 118 \u00b1 34 nmol\/l (p < 0.001) and serum 1,25(OH)<sub>2<\/sub>D levels increased from 7.7 \u00b1 5 to 30.5 \u00b1 15 pmol\/l (p < 0.001) with a median increase of 20 pmol\/l. The mean serum calcium level increased from 2.19 \u00b1 0.1 to 2.25 \u00b1 0.1 mmol\/l (p = 0.009), the intact parathyroid hormone (iPTH) level decreased from 144 \u00b1 108 to 108 \u00b1 63 pg\/ml (p = 0.05), and the bone alkaline phosphatase (BALP) level remained unchanged. The serum phosphate level increased slightly from 1.22 \u00b1 0.3 to 1.34 \u00b1 0.2 mmol\/l (p = 0.04) with reduced hypophosphatemia. Compared with the responders (n = 24), most of the nonresponders (n = 19) were diabetic (63 vs. 29%, p = 0.02) and had a lesser increase of their 25(OH)D serum level. The serum level of FGF-23 was not significant. A positive correlation was observed between serum 1,25(OH)<sub>2<\/sub>D and serum 25(OH)D levels after 6 months of 25(OH)D<sub>3<\/sub> treatment (p = 0.02). <i>Conclusion:<\/i> The Kidney Disease Outcomes Quality Improvement (KDOQI) guidelines do not recommend checking and treating vitamin D deficiency in chronic kidney disease (CKD) stage 5 patients due to the supposed lack of 1,25(OH)<sub>2<\/sub>D production. These data confirm persistent renal or extra-renal production of 1,25(OH)<sub>2<\/sub>D in HD patients after 6 months of 25(OH)D<sub>3<\/sub> administration. Diabetes is the main factor associated with impaired 1,25(OH)<sub>2<\/sub>D production. 25(OH)D<sub>3 <\/sub>administration corrects vitamin D deficiency with few effects on mineral metabolism and stability of bone turnover markers.<\/jats:p>","DOI":"10.1159\/000151534","type":"journal-article","created":{"date-parts":[[2008,8,25]],"date-time":"2008-08-25T05:25:00Z","timestamp":1219641900000},"page":"c58-c65","source":"Crossref","is-referenced-by-count":73,"title":["Evidence for Persistent Vitamin D 1-Alpha-Hydroxylation in Hemodialysis Patients: Evolution of Serum 1,25-Dihydroxycholecalciferol after 6 Months of 25-Hydroxycholecalciferol Treatment"],"prefix":"10.1159","volume":"110","author":[{"given":"G.","family":"Jean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Terrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Hurot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lorriaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Mayor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chazot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra070553"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1542-4758.2007.00186.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2803%2900826-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI110501"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1988.190"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-72-1-157"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200419081"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2003.18.7.1227"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118061"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.1997.12.3.347"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2005.02.029"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2FMAJ.0b013e31803bb129"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1258%2F000456306775141650"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00474.2004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jsbmb.2006.12.054"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199803193381201"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2000.19093"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-59-6-1063"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1677%2Fjme.0.0250141"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1989.64"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-139X.2007.00302.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpneph0189"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T19:46:45Z","timestamp":1715975205000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/NEC\/article\/doi\/10.1159\/000151534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,25]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000151534","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,25]]}}}