{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:10:14Z","timestamp":1770217814940,"version":"3.49.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Cryptorchidism is the most common genital anomaly in men. The <i>INSL3\/LGR8<\/i> system is involved in testicular descent via gubernacular development. INSL3 binds with high affinity to its receptor LGR8 and receptor activation is associated with cAMP signaling. Analysis of human <i>INSL3 <\/i>and <i>LGR8 <\/i>mutations confirms that some cases of cryptorchidism are caused by mutations in these genes. The T222P mutation is the only one within the <i>LGR8<\/i> gene associated with the cryptorchidism phenotype. A strong association of the T222P mutation with cryptorchidism was found in an Italian population. Due to the same mutation being found in patients within the Mediterranean area, a possible founder effect of this mutation is supposed. <i>Methods:<\/i> We screened 109 patients with cryptorchidism and 250 controls in a Moroccan population. <i>Results:<\/i> We found that 3 of the 109 patients tested carry the T222P mutation and 4 individuals in the control group also carry the mutation. <i>Conclusions:<\/i> Our results show in fact that the same mutation is present in the Moroccan population, but an association between cryptorchidism and the T222P mutation was not found.<\/jats:p>","DOI":"10.1159\/000151596","type":"journal-article","created":{"date-parts":[[2008,9,7]],"date-time":"2008-09-07T19:40:56Z","timestamp":1220816456000},"page":"236-239","source":"Crossref","is-referenced-by-count":19,"title":["No Association between T222P\/LGR8 Mutation and Cryptorchidism in the Moroccan Population"],"prefix":"10.1159","volume":"70","author":[{"given":"Brahim","family":"El Houate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Rouba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Imken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hicham","family":"Sibai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelaziz","family":"Chafik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Redouane","family":"Boulouiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elbakkay","family":"Chadli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohmmed","family":"Hassar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"McElreavey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhamid","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2605.2005.00538.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fgene.1029"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fme.13.5.681"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F11.19.2309"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.C200398200"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M212457200"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1065654"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fmolehr%2Fgah205"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030359"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpendo.00228.2006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2007.00244.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000096089"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T19:30:19Z","timestamp":1737142219000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/HRP\/article\/doi\/10.1159\/000151596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000151596","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}