{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:00:20Z","timestamp":1789189220034,"version":"build-2803163510"},"reference-count":9,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Persistent proteinuria is a sign of renal damage caused by several factors, but it is itself a cause of tubular injury leading to chronic renal failure. Neutrophil gelatinase-associated lipocalin (NGAL) is a stress protein released by tubular cells which urinary excretion (uNGAL) increases in response to various stimuli. &lt;i&gt;Methods:&lt;\/i&gt; In the present study we analyzed uNGAL levels in 23 macroproteinuric patients with membranous glomerulonephritis. &lt;i&gt;Results:&lt;\/i&gt; In these subjects, uNGAL concentrations were significantly higher than in controls, directly correlated with proteinuria and inversely related to residual renal function. Patients were further categorized into two groups, according to a cut-off baseline uNGAL value of 350 ng\/ml and evaluated during a 1-year follow-up period. After 12 months, subjects with higher uNGAL levels showed a significant worsening in baseline renal function and a 3.36 risk ratio of developing a severe decrease in GFR (\u226750% of baseline values) compared with others. &lt;i&gt;Conclusions:&lt;\/i&gt; These findings suggest that NGAL may play a key role in tubular adaptations to persistent macroproteinuria. Furthermore, a new, interesting application of NGAL measurement could be proposed in clinical nephrology as a predictor of worsening renal function in patients affected by chronic kidney disease.<\/jats:p>","DOI":"10.1159\/000151665","type":"journal-article","created":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T12:12:12Z","timestamp":1220271132000},"page":"274-279","source":"Crossref","is-referenced-by-count":62,"title":["Pathological and Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin in Macroproteinuric Patients with Worsening Renal Function"],"prefix":"10.1159","volume":"31","author":[{"given":"Davide","family":"Bolignano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Coppolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lacquaniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Nicocia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Buemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006040377"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002165"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.22008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000145013.44578.45"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006080882"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.055003890.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00403.2005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000093961"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2974811-X"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T21:22:13Z","timestamp":1726176133000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/KBR\/article\/doi\/10.1159\/000151665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000151665","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}