{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:20:15Z","timestamp":1773922815860,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Aims:<\/i> To investigate the efficacy and safety of postoperative topical cyclosporine A 0.05% (tCsA) (Restasis\u00ae, Allergan Pharmaceutical) eye drops in preventing the recurrence of pterygium. <i>Methods:<\/i> 31 patients with bilateral pterygium were examined between January 2006 and February 2007. During a 1-year follow-up, the right eyes of the patients assigned as the treatment group were treated by tCsA and the left eyes were considered as the control group. <i>Results:<\/i> The pterygium recurred in 4 (12.9%) of 31 right eyes in the treatment group and in 14 (45.2%) of 31 left eyes in the control group (p = 0.005). The mean follow-up \u00b1 SD was 9.39 \u00b1 4.14 months (range, 1 to 12 months). The control group had a 7.37 times higher risk of recurrence in pterygium compared with the treatment group (OR = 0.1357, p = 0.0051). A statistically significant difference in recurrence-free probabilities was found for the treatment and control groups (log-rank test; p = 0.006). A multivariate Cox regression model showed that age (p = 0.0093) and tCsA (p = 0.0103) were independent statistically significant impacts on recurrence-free time for pterygium. <i>Conclusion:<\/i> This study suggests that primary excision of pterygium with postoperative instillation of 0.05% cyclosporine is both safe and efficient.<\/jats:p>","DOI":"10.1159\/000151740","type":"journal-article","created":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T09:47:23Z","timestamp":1220262443000},"page":"391-396","source":"Crossref","is-referenced-by-count":32,"title":["Topical Cyclosporine A in the Prevention of Pterygium Recurrence"],"prefix":"10.1159","volume":"222","author":[{"given":"Ozlem","family":"Yalcin Tok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Burcu Nurozler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gul","family":"Ergun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Akbas Kocaoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunay","family":"Duman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2899%2990092-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2006.095018"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F02713689408999878"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-200308000-00007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0039-6257%2888%2990071-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-9071.1991.tb00661.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1742-1241.2004.00007.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0420.1999.770206.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12009-002-0054-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6701728"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-199311000-00004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000268041"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS1054-3589%2808%2960276-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2898%2995034-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-9071.1991.tb00639.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.64.7.496"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-200103000-00011"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9394%2888%2990613-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109%2F02713688808997247"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00919028"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1755-3768.1976.tb01265.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-199709000-00010"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0162-3109%2800%2900192-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-199311000-00008"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1997.tb02134.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900035-X"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2961958-8"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/151740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T22:33:41Z","timestamp":1726180421000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/OPH\/article\/doi\/10.1159\/000151740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000151740","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}