{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:05:22Z","timestamp":1789877122327,"version":"4.0.1"},"reference-count":47,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,9,11]],"date-time":"2008-09-11T00:00:00Z","timestamp":1221091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,9,11]],"date-time":"2008-09-11T00:00:00Z","timestamp":1221091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Macrophages express various classes of pattern recognition receptors involved in innate immune recognition of artificial, microbial and host-derived ligands. These include the scavenger receptors (SRs), which are important for phagocytosis, and the Toll-like receptors (TLRs) involved in microbe sensing. The class A macrophage scavenger receptor (SR-A) and macrophage receptor with a collagenous structure (MARCO) display similar domain structures and ligand-binding specificity, which has led to the assumption that these two receptors may be functionally redundant. In this study we show that SR-A and MARCO differentially recognise artificial polyanionic ligands as well as surface proteins from the pathogenic bacterium &lt;i&gt;Neisseria meningitidis&lt;\/i&gt;. We show that, while acetylated low-density lipoprotein (AcLDL) is a strong ligand for SR-A, it is not a ligand for MARCO. Of the neisserial proteins that were SR ligands, some were ligands for both receptors, while other proteins were only recognised by either SR-A or MARCO. We also analysed the potential of these ligands to act as TLR agonists and assessed the requirement for SR-A and MARCO in pro-inflammatory cytokine induction. SR ligation alone did not induce cytokine production; however, for proteins that were both SR and TLR ligands, the SRs were required for full activation of TLR pathways.<\/jats:p>","DOI":"10.1159\/000155227","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T14:03:17Z","timestamp":1228485797000},"page":"153-163","source":"Crossref","is-referenced-by-count":30,"title":["SR-A, MARCO and TLRs Differentially Recognise Selected Surface Proteins from&lt;i&gt; Neisseria meningitidis&lt;\/i&gt;: an Example of Fine Specificity in Microbial Ligand Recognition by Innate Immune Receptors"],"prefix":"10.1159","volume":"1","author":[{"given":"Annette","family":"Pl\u00fcddemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Sankala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Savino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagrazia","family":"Pizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rino","family":"Rappuoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Tryggvason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamon","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2006.02.015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2802%2901201-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.23.021704.115816"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.coi.2005.11.012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00041433-199710000-00006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.8.4530"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.87.23.9133"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2F343570a0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2F343531a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2F364343a0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M701750200"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.200535660"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830250224"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1165%2Frcmb.2006-0197OC"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-2478%2897%2900077-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20031237"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.180.2.705"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS1286-4579%2800%2900297-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ymeth.2007.06.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M513628200"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.91.5.1863"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2895%2990514-6"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2F352342a0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.21.120601.141126"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M700188200"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M009164200"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.74.2.940-946.2006"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.200535389"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.70.10.5346-5354.2002"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.00124-06"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature03253"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.immuni.2005.03.008"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016%2FS0076-6879%2872%2925016-9"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.287.5459.1816"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038%2F386292a0"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-1759%2883%2990442-8"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.116.1.95"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jim.2007.10.002"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M204494200"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.76.1.333"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1194%2Fjlr.M600027-JLR200"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2567.2001.01222.x"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1189%2Fjlb.0705357"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2800%2981838-3"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M011117200"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20040731"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1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