{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:53:37Z","timestamp":1745470417002,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objectives:<\/i> High-density lipoprotein (HDL) cholesterol elevation is associated with an improved outcome in patients with atherosclerotic disease. Niaspan\u00ae, a prolonged-release nicotinic acid, was evaluated during the Niaspan-Induced HDL Elevation for Optimizing Risk Control (NEMO) study in The Netherlands. <i>Methods:<\/i> NEMO was a 6-month, prospective, observational, multicentre, open-label study. Niaspan was prescribed in statin-treated patients with known or suspected atherosclerotic disease. The main outcome measures were treatment-related adverse drug reactions (ADRs) and effects on lipids and cardiovascular-risk score based on the algorithm derived from the Prospective Cardiovascular M\u00fcnster study. <i>Results:<\/i> 612 patients were included in The Netherlands. Flushing was the most common ADR (29% of patients during the first month of treatment). The main reasons for treatment discontinuation were flushing (10.5%), patient request (8.0%) and being lost to follow-up (6.0%). About half of all patients (52%) continued treatment after the study. Tolerability was rated \u2018good\u2019 or \u2018very good\u2019 in 54% of these patients. HDL cholesterol increased by 23% from baseline, and triglycerides were reduced by 16%, with little change in low-density lipoprotein or total cholesterol. Cardiovascular risk score was reduced by 3.3 points. <i>Conclusions:<\/i> The use of the prolonged-release nicotinic acid Niaspan in patients with or at risk for atherosclerotic disease showed good tolerability, a marked increase in HDL cholesterol and a reduced cardiovascular risk score.<\/jats:p>","DOI":"10.1159\/000155896","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:30:21Z","timestamp":1492551021000},"page":"313-318","source":"Crossref","is-referenced-by-count":3,"title":["Prolonged-Release Nicotinic Acid in Patients with Atherosclerotic Disease in The Netherlands"],"prefix":"10.1159","volume":"41","author":[{"given":"D.","family":"Poldermans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dunkelgrun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Schouten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Hostalek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199202063260605"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0195-668X%2803%2900347-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fsum011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967394-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fsui040"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2916895-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.256.20.2835"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9150%2896%2905852-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.608679"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1067%2Fmhj.2000.110090"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fsui041"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fsul043"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fsui042"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0026-0495%2898%2990284-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000148955.19792.8D"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1185%2F030079906X148508"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1185%2F030079907X199682"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc0302.102575"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.286.11.1317"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199908053410604"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067%2Fmhj.2000.110090"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ehj.2003.09.002"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1185%2F030079905X74871"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1185%2F030079904125004402"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2003.08.061"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa070635"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa071359"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1161%2FATVBAHA.106.138347"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000256728.60226.77"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fsui038"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/155896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/155896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:07:59Z","timestamp":1745456879000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000155896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000155896","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[2008]]}}}