{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:54:09Z","timestamp":1792792449615,"version":"4.5.0"},"reference-count":60,"publisher":"S. Karger AG","issue":"4-6","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Aging is associated with a decline in immune function (immunosenescence), a condition known to correlate with increased incidence of cancer as well as infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. Circulating melatonin decreases with age, and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes and macrophages. It also stimulates the production of natural killer cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from natural killer cells and T helper lymphocytes are enhanced by melatonin. Melatonin has the potential therapeutic value to enhance immune function in aged individuals.<\/jats:p>","DOI":"10.1159\/000156470","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T14:18:13Z","timestamp":1227968293000},"page":"272-278","source":"Crossref","is-referenced-by-count":116,"title":["Melatonin and the Immune System in Aging"],"prefix":"10.1159","volume":"15","author":[{"given":"Daniel P.","family":"Cardinali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Esquifino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkataramanujan","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seithikurippu R.","family":"Pandi-Perumal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.it.2004.05.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0039.2007.00891.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1474-9728.2004.00109.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186%2F1742-4933-2-17"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0959-9673.2006.00474.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1021%2Fja01543a060"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017%2FS0952523806230189"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1020107915919"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1385%2FENDO%3A27%3A2%3A137"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00018-007-6435-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-079X.2000.280401.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.smrv.2004.08.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-079X.2006.00407.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2007.10.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00424-007-0242-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1196%2Fannals.1356.028"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080%2F07420520500464361"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tmaid.2007.12.002"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2007.10.007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2891%2990146-M"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2F0303-7207%2875%2990019-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4103%2F0019-5359.28983"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-06-1776"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186%2F1744-9081-2-15"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjhyper.2005.07.013"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1742-1241.2006.01191.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjmed.2003.07.017"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cdp.2007.02.001"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10552-005-9011-8"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10552-005-9001-x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-079X.2000.290301.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159%2F000054684"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007020170061"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2FS1286-4579%2801%2901443-5"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02786468"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exger.2003.09.017"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016%2FS1040-8428%2801%2900168-8"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002%2F1521-4141%28200206%2932%3A6%3C1524%3A%3AAID-IMMU1524%3E3.0.CO%3B2-E"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2899%2900271-4"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1517%2F13543784.10.3.467"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-079X.1999.tb00578.x"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejphar.2004.08.015"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2826.2002.00823.x"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1159%2F000110635"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-079X.2004.00149.x"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1196%2Fannals.1332.013"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016%2FS0531-5565%2801%2900182-6"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1006659401385"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016%2FS0047-6374%2803%2900013-7"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exger.2003.11.016"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016%2FS0047-6374%2800%2900210-4"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-2478%2803%2900068-3"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-079X.2001.310304.x"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-079X.2000.290204.x"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2826.2001.00627.x"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1010968611716"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.6.3071"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1093%2Fintimm%2F14.2.201"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.200323575"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejphar.2007.06.011"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/156470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/156470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:39:46Z","timestamp":1745455186000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000156470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":60,"journal-issue":{"issue":"4-6","published-online":{"date-parts":[[2008,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000156470","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"value":"1021-7401","type":"print"},{"value":"1423-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}