{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:52:20Z","timestamp":1745470340020,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2008]]},"abstract":"During the initial phase of chronic hepatitis B virus (HBV) infection, serum HBV DNA levels are high. Contrarily, fibrosis, cirrhosis and hepatocellular carcinoma have been found in patients with lower serum HBV DNA levels. The aim of this study is to clarify HBV DNA level dynamics of serum apportioned by the same hepatic parenchyma cell volume (HPCV) in hepatic fibrosis stages 1\u20134 during the natural history of chronic hepatitis B. Serum HBV DNA levels were evaluated by real-time polymerase chain reaction. Further, serum HBV DNA levels were apportioned by and compared with the same HPCV in hepatic fibrosis stages 1\u20134, respectively. Serum HBV DNA levels were 8.91 \u00d7 10<sup>6<\/sup> \u00b1 4.37 \u00d7 10<sup>1<\/sup>, 8.13 \u00d7 10<sup>6<\/sup> \u00b1 7.41 \u00d7 10<sup>1<\/sup>, 9.55 \u00d7 10<sup>5<\/sup> \u00b1 1.02 \u00d7 10<sup>2<\/sup>, and 4.07 \u00d7 10<sup>5<\/sup> \u00b1 7.24 \u00d7 10<sup>1<\/sup> copies\/ml, respectively; there were differences among hepatic fibrosis stages 1\u20134 (p < 0.021\u20130.000). However, serum HBV DNA levels apportioned by the same volume of hepatic parenchyma cells in hepatic fibrosis stages 1\u20134 were 3.47 \u00d7 10<sup>10<\/sup> \u00b1 8.71 \u00d7 10<sup>2<\/sup>, 1.02 \u00d7 10<sup>11<\/sup> \u00b1 9.55 \u00d7 10<sup>2<\/sup>, 1.41 \u00d7 10<sup>10<\/sup> \u00b1 2.57 \u00d7 10<sup>3<\/sup>, and 3.72 \u00d7 10<sup>10<\/sup> \u00b1 3.02 \u00d7 10<sup>3<\/sup> with HPCV proportions 65.9, 62.7, 58.9, and 53.3%, respectively; there were no differences among hepatic fibrosis stages 1\u20134 (p > 0.203\u20130.967).Following the progression of hepatic fibrosis from stage 1 to 4, ongoing decline of HPCV is responsible for a declining trend of serum HBV DNA levels.<\/jats:p>","DOI":"10.1159\/000156482","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T11:47:28Z","timestamp":1223034448000},"page":"235-240","source":"Crossref","is-referenced-by-count":6,"title":["Decline of Serum HBV DNA and No Change Apportioned by the Same Hepatic Parenchyma Cell Volume from Hepatic Fibrosis Stage 1 to Stage 4 during the Natural History of Chronic Hepatitis B"],"prefix":"10.1159","volume":"51","author":[{"given":"Wei-Min","family":"Ke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Bin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Na","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Qiu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-He","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Liang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,9,24]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1046%2Fj.1365-2893.2003.00487.x"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1053%2Fgast.2001.24839"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1007%2Fs10620-006-3175-2"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1111%2Fj.1365-2893.2005.00688.x"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1053%2Fj.gastro.2005.11.016"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1086%2F374226"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1080%2F00365520600979831"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1007%2Fs00535-007-2015-2"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1111%2Fj.1478-3231.2006.01418.x"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016%2Fj.antiviral.2007.02.003"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1136%2Fgut.2004.062208"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.2169%2Finternalmedicine.42.941"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1034%2Fj.1600-0676.2001.210107.x"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1080%2F00365520410006332"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016%2F0270-9139%2894%2990250-X"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1157%2F13067622"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1002%2Fhep.21627"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1111%2Fj.1478-3231.2004.00908.x"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/156482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/156482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:39:52Z","timestamp":1745455192000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000156482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000156482","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"type":"print","value":"0300-5526"},{"type":"electronic","value":"1423-0100"}],"subject":[],"published":{"date-parts":[[2008]]}}}