{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:43:25Z","timestamp":1777909405407,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,9,23]],"date-time":"2008-09-23T00:00:00Z","timestamp":1222128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,9,23]],"date-time":"2008-09-23T00:00:00Z","timestamp":1222128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"abstract":"<jats:p>Investigations into the relationship between pHi and tension were carried out in rat mesenteric resistance arteries. Acute acidosis, induced by ammonium chloride pre-pulse, led to variable and transient tension development, but simultaneous removal of extracellular sodium led to a sustained rise in tension associated with maintained intracellular acidification. Dependence of tension and pH&lt;sub&gt;i&lt;\/sub&gt; recovery from acute acidosis on Na\/H exchange and anion exchange pathways was demonstrated using pharmacological inhibitors. Additionally, removal of HCO&lt;sub&gt;3&lt;\/sub&gt; suggested the anion pathway involved was Na-dependent HCO&lt;sub&gt;3&lt;\/sub&gt; transport. Removal of extracellular calcium, or pharmacological inhibition of voltage-dependent calcium channels, prevented the tension development in response to NH&lt;sub&gt;4&lt;\/sub&gt;Cl pre-pulse in an Na-free medium, but did not affect pH&lt;sub&gt;i&lt;\/sub&gt;. Intracellular acidosis resulting from elevation of the P&lt;sub&gt;CO2&lt;\/sub&gt;resulted in initial vasoconstriction followed by profound vasodilatation of arteries pre-contracted with noradrenaline (NA). The response to alkalosis induced by NH&lt;sub&gt;4&lt;\/sub&gt;C1 or by lowering the Pco&lt;sub&gt;2&lt;\/sub&gt; ted to initial dilatation followed by potentiation of NA-induced tension.<\/jats:p>","DOI":"10.1159\/000158948","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T06:23:39Z","timestamp":1222237419000},"page":"330-340","source":"Crossref","is-referenced-by-count":28,"title":["Relationships between pH\n                    <sub>i<\/sub>\n                    and Tension in Isolated Rat Mesenteric Resistance Arteries"],"prefix":"10.1159","author":[{"given":"J.G.","family":"Matthews","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Graves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Poston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,9,23]]},"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000158948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:30:00Z","timestamp":1777645800000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000158948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000158948","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,23]]}}}