{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:43:38Z","timestamp":1789771418594,"version":"4.0.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Biliary tract cancers are among the most aggressive tumors with a poor prognosis. We conducted a phase II study on combination chemotherapy consisting of S-1 and oxaliplatin in previously untreated patients . <i>Methods:<\/i> Patients were treated with S-1 40 mg\/m<sup>2<\/sup> twice daily, administered orally on days 1\u201328, and 85 mg\/m<sup>2<\/sup> of oxaliplatin, administered via an intravenous 90-min infusion on days 1, 15 and 29. Treatments were repeated every 6 weeks. <i>Results:<\/i> 15 patients were enrolled: 9 patients (60%) had intrahepatic and 3 (20%) had extrahepatic cholangiocarcinoma, 2 (13.3%) had cancer of the ampulla of Vater and 1 patient had gall bladder cancer. Partial response was observed in 1 of the 15 (6.7%) patients. Stable disease was observed in 4 patients (26.7%). The median time to progression was 1.4 months (95% confidence interval, CI, 0.9\u20131.9), and the median overall survival was 3.1 months (95% CI, 0.0\u20137.0). Grade 3 hematologic toxicities included neutropenia (1, 6.7%) and thrombocytopenia (1, 6.7%). As the response rate in stage I did not justify progression to stage II (\u22672\/15), this study had to be discontinued in accordance with the established protocols. <i>Conclusion:<\/i> The combination chemotherapy with S-1 and oxaliplatin utilized in this study resulted in no promising antitumor activity.<\/jats:p>","DOI":"10.1159\/000159624","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T05:49:01Z","timestamp":1223012941000},"page":"479-484","source":"Crossref","is-referenced-by-count":7,"title":["Phase II Trial of S-1 in Combination with Oxaliplatin in Previously Untreated Patients with Recurrent or Inoperable Biliary Tract Cancer"],"prefix":"10.1159","volume":"54","author":[{"given":"Sung Yong","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon Gu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hyo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4143%2Fcrt.2004.36.2.103"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2407-2-10"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6603648"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00001813-199607000-00010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00685830"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2898%2900211-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000012099"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000096002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1054%2Fbjoc.2000.1236"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6692031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdm439"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F92.3.205"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000070622"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.21741"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Foxfordjournals.annonc.a010676"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00000421-200008000-00023"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000011961"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00001813-200104000-00006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00280-006-0380-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.21591"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1245%2Fs10434-007-9539-9"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6602208"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6603334"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdh351"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00280-007-0444-5"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6604178"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/159624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/159624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:08:06Z","timestamp":1745456886000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000159624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000159624","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}