{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:52:24Z","timestamp":1745470344000,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>We report a case of trisomy 21 mosaicism detected upon amniocentesis in a 36-year-old woman. Ultrasound examination at 23weeks\u2019 gestation showed a fetus with hydrops, pulmonary hypoplasia, oligohydramnios, thickened placenta, and intrauterine growth retardation. Cytogenetic analysis revealed low-percentage (6%) mosaicism for trisomy 21. Hydrops fetalis and thickened placenta are uncommon findings in fetuses affected by trisomy 21 mosaicism. A short review of the literature is given regarding the sonographic findings associated with trisomy 21 mosaicism, and the genetic counseling in such cases.<\/jats:p>","DOI":"10.1159\/000160218","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T11:47:28Z","timestamp":1223034448000},"page":"310-312","source":"Crossref","is-referenced-by-count":3,"title":["Hydrops Fetalis, Thickened Placenta and Other Sonographic Findings in a Low-Level Trisomy 21 Mosaicism: A Case Report"],"prefix":"10.1159","volume":"24","author":[{"given":"S.","family":"Sifakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Koukoura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mantas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Velissariou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Koumantakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199601%2916%3A1%3C1%3A%3AAID-PD816%3E3.0.CO%3B2-W"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199902%2919%3A2%3C142%3A%3AAID-PD486%3E3.0.CO%3B2-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1970120702"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-994660"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199908%2919%3A8%3C764%3A%3AAID-PD618%3E3.0.CO%3B2-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199812%2918%3A12%3C1308%3A%3AAID-PD443%3E3.0.CO%3B2-H"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000264470"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2Fplac.2001.0658"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.1923"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28200002%2920%3A2%3C103%3A%3AAID-PD761%3E3.0.CO%3B2-K"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199703%2917%3A3%3C201%3A%3AAID-PD56%3E3.0.CO%3B2-H"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.620"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/160218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/160218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:41:28Z","timestamp":1745455288000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000160218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000160218","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2008]]}}}