{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:57Z","timestamp":1790617257403,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objective:<\/i> Few studies have explored the relationship between orthostatic hypotension (OH) and cognition. The aim of this study was to examine the association of OH with cognitive impairment and decline in a cohort of Chinese elderly, and its effect modification by blood pressure (BP) status at baseline. <i>Method:<\/i> Among 2,321 community-living older adults, free of cardiovascular disease and stroke, baseline BP measurements were used to determine the presence of OH and categorize participants as hypotensives, normotensives or hypertensives. The Mini-Mental State Examination (MMSE) was used to assess cognitive impairment (MMSE score <24). Cognitive decline (decrease in MMSE score by \u22671) was assessed from 1 to 2 years of follow-up for 1,347 participants without baseline cognitive impairment. <i>Results:<\/i> Mean age of the subjects was 65.5 years and 381 (16.6%) showed OH. OH was not associated with cognitive impairment overall. However, among hypotensives, OH increased the odds of cognitive impairment (OR = 4.1, 95% CI = 1.11\u201315.1), while hypertensives with OH showed reduced odds of cognitive impairment (OR = 0.48, 95% CI = 0.26\u20130.90). Among cognitively intact participants, OH was not associated with cognitive decline overall or in BP subgroups. <i>Conclusion:<\/i> The increased risk of cognitive impairment in hypotensives with OH suggests that hypotension with OH may be an early comorbid marker of a primary incipient dementia.<\/jats:p>","DOI":"10.1159\/000160955","type":"journal-article","created":{"date-parts":[[2008,10,11]],"date-time":"2008-10-11T20:33:17Z","timestamp":1223757197000},"page":"239-246","source":"Crossref","is-referenced-by-count":53,"title":["Orthostatic Hypotension, Hypotension and Cognitive Status: Early Comorbid Markers of Primary Dementia?"],"prefix":"10.1159","volume":"26","author":[{"given":"Philip Lin Kiat","family":"Yap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Niti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng Bee","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Pin","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2891%2990012-M"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.155.9.930"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2901923-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.58.10.1640"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2990608-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02291403"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.1562"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2899%2902113-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1993.tb05509.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2894%2991177-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1532-5415.2005.00533.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F01.JGP.0000235710.17450.9a"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.archger.2005.12.001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2F1099-1166%28200009%2915%3A9%3C824%3A%3AAID-GPS207%3E3.0.CO%3B2-C"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2002.tb04816.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.60.2.223"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000154249"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2903086-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.162.18.2046"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.63.2.153"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.107.486407"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.107.488403"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.277.16.1299"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/160955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/160955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:49:35Z","timestamp":1745455775000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000160955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000160955","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}