{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:52:49Z","timestamp":1745470369099,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The apolipoprotein E (ApoE) genotype has been confirmed as the major genetic risk factor for late-onset Alzheimer\u2019s disease (AD). How the ApoE genotype and brain morphology relate to each other is only partly understood, particularly in mild cognitive impairment, the assumed prestage of AD. &lt;i&gt;Methods:&lt;\/i&gt; A total of 83 subjects with mild cognitive impairment (aging-associated cognitive decline criteria) were investigated with optimized voxel-based morphometry (VBM). We tested for differences in gray and white matter densities between groups according to their ApoE status, i.e. &amp;#917;4 allele noncarriers (n = 42), subjects with one &amp;#917;4 allele (n = 27) and subjects with two &amp;#917;4 alleles (n = 14). &lt;i&gt;Results:&lt;\/i&gt; In individuals carrying two &amp;#917;4 alleles, VBM revealed a decline in gray matter density predominantly in the medial temporal lobe region. Subjects with a single copy of the &amp;#917;4 allele exhibited gray matter atrophy in the right inferior frontal gyrus. With respect to white matter changes, atrophy was only found in subjects homozygous for &amp;#917;4 and confined to the right superior and middle temporal gyrus. &lt;i&gt;Conclusion:&lt;\/i&gt; Our findings support the hypothesis that the ApoE genotype in mild cognitive impairment might be associated with structural changes typically found in the early stages of AD.<\/jats:p>","DOI":"10.1159\/000161054","type":"journal-article","created":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T07:39:40Z","timestamp":1224488380000},"page":"300-305","source":"Crossref","is-referenced-by-count":18,"title":["Apolipoprotein E Polymorphism and Brain Morphology in Mild Cognitive Impairment"],"prefix":"10.1159","volume":"26","author":[{"given":"Philipp A.","family":"Thomann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann-Sophie","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasco","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Toro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Essig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2003.12.023"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.3283935"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000192102.41141.9e"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000109150"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000093263"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.63.1.63"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000204180.25361.48"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1017%2FS1041610294001626"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.162.11.2071"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.39.9.1159"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1006%2Fnimg.2001.0786"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.62.6.953"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006%2Fnimg.2000.0582"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F01.wnr.0000174058.49521.16"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000238079.00472.3a"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.164.6.916"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00308809"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000113698"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/161054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/161054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:50:52Z","timestamp":1745455852000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000161054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000161054","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2008]]}}}