{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:52:51Z","timestamp":1781221971836,"version":"3.54.1"},"reference-count":40,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T00:00:00Z","timestamp":1223596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T00:00:00Z","timestamp":1223596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> Previous results demonstrated that sensitization to specific olive pollen allergens could be related with a different clinical pattern (asthma and\/or rhinitis), and that specific patterns of sensitization are regulated by different HLA class II antigens. The authors analyze the possible implication of 7 genetic polymorphisms described as asthma susceptibility genes: <i>IL13<\/i> (C\u20131112T and R130Q), <i>IL4RA<\/i> (I50V, Q551R), <i>IL5<\/i> (C\u2013746T) and <i>ADRB2<\/i> (Q27E and R16G) in specific olive pollen allergic sensitization. <i>Methods:<\/i> The authors genotyped seven polymorphisms of the <i>IL13, IL4RA, IL5<\/i> and <i>ADRB2<\/i> genes in 146 patients allergic to olive pollen with seasonal rhinitis\/asthma and 50 controls using the polymerase chain reaction-restriction fragment length polymorphism and real-time polymerase chain reaction techniques. <i>Results:<\/i> Two polymorphisms of <i>IL13<\/i> were associated with allergy to olive pollen: the TT genotype of <i>IL13<\/i> C\u20131112T was decreased (odds ratio, OR = 0.35, p = 0.006) whereas the RQ heterozygous genotype of <i>IL13<\/i> R130Q increased in patients allergic to olive pollen (OR = 3.12, p = 0.009). The combined analysis of two <i>IL4RA<\/i> single nucleotide polymorphisms (SNPs) (I50V and Q551R) showed an association with asthma: <i>IL4RA<\/i> V50\/Q551 was associated with risk (OR = 2.48, p = 0.007) whereas the <i>IL4RA<\/i> V50R551 haplotype was associated with protection (OR = 0.31, p = 0.003). <i>Conclusions:<\/i> The <i>IL13<\/i> polymorphisms under study were associated with specific allergy to olive pollen: the <i>IL13<\/i> C\u20131112T polymorphism as a protective factor and the <i>IL13<\/i> R130Q polymorphism as a risk factor. Interestingly, although single polymorphisms of <i>IL4RA<\/i> are not associated with any phenotype analyzed, the interaction between <i>IL4RA<\/i> I50V\/Q551R was strongly associated with the asthma phenotype. <i>IL13<\/i> and <i>IL4RA<\/i> could be relevant markers for allergy to olive pollen and asthma development.<\/jats:p>","DOI":"10.1159\/000161583","type":"journal-article","created":{"date-parts":[[2008,10,11]],"date-time":"2008-10-11T20:33:17Z","timestamp":1223757197000},"page":"228-238","source":"Crossref","is-referenced-by-count":27,"title":["Analysis of Polymorphisms in Olive Pollen Allergy: <i>IL13, IL4RA, IL5 <\/i>and <i>ADRB2<\/i> Genes"],"prefix":"10.1159","volume":"148","author":[{"given":"Elena","family":"Llanes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Quiralte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Chac\u00e1rtegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"del 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