{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:43:47Z","timestamp":1777945427850,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T00:00:00Z","timestamp":1222992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T00:00:00Z","timestamp":1222992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol Microbiol (Basel)"],"abstract":"<jats:p>The effect of 3-methylcholanthrene on carbon tetrachloride-induced cirrhosis of the liver was studied in young and aged male and female Buffalo strain rats. Animals 8 and 76 weeks of age were used. The cirrhosis was more often severe in the older animals given both chemical simultaneously than in those given only carbon tetrachloride. Animals 8 weeks of age did not develop hepatic vein thrombosis or cholangiofibrosis. These lesions were present in 76-week-old rats receiving carbon tetrachloride; however, the incidence was significantly increased in animals given both carbon tetrachloride and 3-methylcholanthrene.<\/jats:p>","DOI":"10.1159\/000162313","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T01:49:01Z","timestamp":1222998541000},"page":"122-131","source":"Crossref","is-referenced-by-count":0,"title":["Hepatic Lesions in Aged Rats Given Carbon Tetrachloride and 3-MethylchoIanthrene"],"prefix":"10.1159","author":[{"given":"M.D.","family":"Reuber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.F.","family":"Dove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,3]]},"container-title":["Pathologia et Microbiologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/162313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000162313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:56:45Z","timestamp":1777723005000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000162313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000162313","archive":["Portico"],"relation":{},"ISSN":["0031-2959","2235-168X"],"issn-type":[{"value":"0031-2959","type":"print"},{"value":"2235-168X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,3]]}}}