{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:44:52Z","timestamp":1777945492921,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T00:00:00Z","timestamp":1222992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T00:00:00Z","timestamp":1222992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Cell Biol"],"abstract":"<jats:p>Osborne-Mendel male and female rats ingesting 0.1, 1.0, 5, 10, or 25 ppm endrin in the diet developed high incidences of maligant tumors in a variety of organs, as well as neoplastic lesions of the liver. The incidence of carcinomas and sarcomas was highest in male rats ingesting 0.1 ppm and in female rats ingesting 0.1 or 1.0 ppm endrin. The tumors were highly malignant and there were some extremely rare or unusual tumors such as Kupffer cell sarcomas of the liver and leiomyosarcomas of the mammary gland and stomach. Carcinomas or sarcomas were also present in the adrenal cortex, mammary gland, thyroid, uterus, lymph nodes, as well as other organs. Male rats also developed an increased incidence of chronic renal disease. It is concluded that endrin is a carcinogen when given to Osborne-Mendel male and female rats in the diet.<\/jats:p>","DOI":"10.1159\/000162888","type":"journal-article","created":{"date-parts":[[2008,10,6]],"date-time":"2008-10-06T06:32:51Z","timestamp":1223274771000},"page":"129-145","source":"Crossref","is-referenced-by-count":1,"title":["Carcinomas, Sarcomas and Other Lesions in Osborne-Mendel Rats Ingesting Endrin"],"prefix":"10.1159","author":[{"given":"Melvin Dwaine","family":"Reuber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,3]]},"container-title":["Experimental Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/162888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000162888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:11:50Z","timestamp":1777723910000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000162888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000162888","archive":["Portico"],"relation":{},"ISSN":["0304-3568","2235-1671"],"issn-type":[{"value":"0304-3568","type":"print"},{"value":"2235-1671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,3]]}}}