{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:26:54Z","timestamp":1790375214180,"version":"4.1.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T00:00:00Z","timestamp":1224201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T00:00:00Z","timestamp":1224201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Dexamethasone treatment is associated with an increased risk of cerebral palsy (CP). Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation. Follow-up of randomized studies concerning early HC treatment is essential to confirm the long-term safety. &lt;i&gt;Objective:&lt;\/i&gt; We hypothesized that early HC treatment in very preterm infants does not impair the neurologic outcome. &lt;i&gt;Methods:&lt;\/i&gt; We report follow-up data from a randomized trial of early HC given for 10 days. Before the HC or placebo treatment, serum cortisol levels were measured. Receiver-operating characteristic was defined. Values below the median were classified as low endogenous cortisol and those above the median as high endogenous cortisol. A meta-analysis was performed. &lt;i&gt;Results:&lt;\/i&gt; Altogether 98% of the 46 surviving infants participated in a follow-up study at a corrected age of 2 years. The growth characteristics were similar between the study groups. The developmental quotients (DQs) of the children with high endogenous cortisol and placebo treatment shortly after birth (100 \u00b1 13) and those with low endogenous cortisol and HC (97 \u00b1 7) were not lower than the DQs of the children with high endogenous cortisol and HC (92 \u00b1 3) or low cortisol and placebo (96 \u00b1 2). According to a meta-analysis of three available trials (411 children), the rate of CP and survival without neurosensory or cognitive impairment was not influenced by HC. &lt;i&gt;Conclusion:&lt;\/i&gt; Early low-dose HC administration had no adverse effects at 2 years of age. Further studies are required to define the target group for neonatal HC.<\/jats:p>","DOI":"10.1159\/000164150","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T11:47:16Z","timestamp":1224244036000},"page":"240-247","source":"Crossref","is-referenced-by-count":53,"title":["Trial of Early Neonatal Hydrocortisone: Two-Year Follow-Up"],"prefix":"10.1159","volume":"95","author":[{"given":"Outi M.","family":"Peltoniemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aulikki","family":"Lano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riina","family":"Puosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneli","family":"Yliherva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bonsante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Anneli","family":"Kari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Ffn.83.3.F177"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa032089"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.104.1.15"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.101.5.e7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.104.6.1258"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-1159"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2004.12.040"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000098168"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.109.2.330"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-3158"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-8749.1992.tb11479.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.104.1.22"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Ffn.74.1.F33"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.105.3.542"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.100.4.e3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.104.1.91"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.110.2.275"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200101113440203"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.109.2.330"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-1238"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2007.00500.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1203%2F01.pdr.0000196377.13816.61"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-1275"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250310002425"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2895%2970464-7"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/164150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/164150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:35:45Z","timestamp":1745454945000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000164150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,17]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000164150","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,17]]}}}