{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:00:05Z","timestamp":1761919205466,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objective:<\/i> DNA repair genes play a key role in maintaining genomic stability and integrity. DNA repair gene polymorphisms, such as those of XRCC3 and xeroderma pigmentosum, complementation group D and G (XPD, XPG), contribute to carcinogenesis. In this study, we investigated the correlation between cervical carcinoma risk and <i>XRCC3, XPD, XPG<\/i> genetic variants. <i>Methods:<\/i> A case-control study of 400 cases including 200 carcinoma, 200 cervical intraepithelial neoplasia (CIN) and 200 normal women was performed. Four single nucleotide polymorphisms (SNPs) (<i>XRCC3<\/i> Thr241Met, <i>XPG<\/i> His1104Asp,<i> XPD <\/i>Asp312Asn, and<i> XPD<\/i> Lys751Gln) were genotyped by mismatch amplification polymerase chain reaction. <i>Results:<\/i> Women carrying homozygous Asp1104Asp genotypes had a significantly decreased risk of cervical or cervical squamous cell carcinoma compared to His1104Asp or His1104His genotypes. Similarly, <i>XPD<\/i> Asn312Asn (AA) reduced the risk of cervical or cervical squamous cell carcinoma. No association of <i>XRCC3<\/i> Thr241Met or <i>XPD<\/i> Lys751Gln and cervical carcinoma was found. None of the 4 SNPs influenced the risk of CIN in our study. <i>Conclusion:<\/i> Our results support the hypothesis that genetic variations in DNA repair genes may contribute to an inherited genetic susceptibility to cervical carcinoma.<\/jats:p>","DOI":"10.1159\/000164220","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T11:03:14Z","timestamp":1229338994000},"page":"356-363","source":"Crossref","is-referenced-by-count":23,"title":["Susceptibility of <i>XRCC3, XPD, <\/i>and <i>XPG<\/i> Genetic Variants to Cervical Carcinoma"],"prefix":"10.1159","volume":"75","author":[{"given":"Xiaohong","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaizeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1086%2F341782"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1056154"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F21.11.1977"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F22.9.1437"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F11.12.1399"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F22.4.593"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F21.12.2219"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1158%2F1055-9965.EPI-03-0053"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2F363182a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.21413"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2Fbgg120"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fmutage%2F17.6.463"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.1433"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F23.4.599"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.11136"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F22.3.403"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2Fbgi115"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2F85798"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.1228"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3835%2802%2900638-9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2003.132"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008918310055"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1086%2F341782"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/164220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/164220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:36:24Z","timestamp":1745454984000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000164220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000164220","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2008]]}}}