{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:26:20Z","timestamp":1789381580980,"version":"build-2803163510"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Atherosclerosis remains clinically mute for a long time and frequently manifests itself with an acute cardiovascular event. The possibility of detecting this disease in a subclinical phase and reducing or reversing its progression is an issue of relevance. Published studies on the association between antioxidant vitamins and carotenoids and carotid intima-media thickness (CIMT) have been inconclusive. <i>Methods:<\/i> We enrolled 220 consecutive, asymptomatic participants. After carotid ultrasound investigation, a medical history was taken, a physical examination was performed and venous blood samples were collected. Venous blood samples were analyzed for concentrations of antioxidant vitamins and carotenoids. <i>Results:<\/i> Low concentrations of vitamin A (p < 0.01), vitamin E (p < 0.001), lycopene (p < 0.01) and \u03b2-carotene (p < 0.001) were significantly associated with carotid atherosclerosis (CIMT \u22670.8 mm). In addition, marginally higher body mass index, plasma haemoglobin and high-density lipoprotein cholesterol were also associated with carotid atherosclerosis, while other laboratory parameters considered in this study (total cholesterol, low-density lipoprotein cholesterol, triglycerides and C-reactive protein) were not significantly associated with carotid atherosclerosis. <i>Conclusions:<\/i> Low plasma concentrations of antioxidant vitamins (A, E, \u03b2-carotene) and lycopene were associated with early carotid atherosclerotic lesions as measured by CIMT. Regular intake of foods rich in lycopene and antioxidant vitamins may slow the progression of atherosclerosis.<\/jats:p>","DOI":"10.1159\/000164691","type":"journal-article","created":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T12:59:05Z","timestamp":1224507545000},"page":"86-90","source":"Crossref","is-referenced-by-count":25,"title":["Plasma Antioxidants and Asymptomatic Carotid Atherosclerotic Disease"],"prefix":"10.1159","volume":"53","author":[{"given":"Graziano","family":"Riccioni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonino","family":"Bucciarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolantonio","family":"D\u2019Orazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"di Ilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Corradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Pennelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia A.","family":"Bazzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2Fhq1201.100221"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2F35025203"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199708073370607"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1517%2F13543784.16.1.25"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198901053200122"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.20.6.1622"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2796.1991.tb00336.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc4601.099486"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.11.5.1245"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.289.19.2560"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2891%2992916-P"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.28.3.665"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2899%2980580-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2896%2900333-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2800%2900403-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000109955.80818.8a"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901676-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2310%2F6650.2007.06043"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067%2Fmhj.2002.120776"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199305203282004"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/164691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/164691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:41:36Z","timestamp":1745455296000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000164691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000164691","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}