{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:10:05Z","timestamp":1745457005703,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T00:00:00Z","timestamp":1224633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T00:00:00Z","timestamp":1224633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; While the glucocorticoid triamcinolone acetonide (9\u03b1-fluoro-16\u03b1-hydroxyprednisolone, TA) has been widely administered as a treatment of ocular inflammation, mineralocorticoids have not been tested for their efficacy. &lt;i&gt;Methods:&lt;\/i&gt; We assessed cellular morphology and actin distribution by immunomicroscopy and light microscopy, membrane permeability with transendothelial resistance and cell surface vascular endothelial growth factor receptor-1 (VEGF-R1) expression by flow cytometry. &lt;i&gt;Results:&lt;\/i&gt; Fludrocortisone acetate was more effective than TA in restoring quiescent morphology and reducing membrane permeability in phorbol-12-myristate-acetate (PMA)-stimulated choroidal endothelial cells (CECs). Each of the corticosteroids inhibited VEGF-R1 cell surface expression in PMA-responsive CECs. &lt;i&gt;Conclusion:&lt;\/i&gt; Mineralocorticoids may be of potential use in reducing vascular permeability in ocular disease.<\/jats:p>","DOI":"10.1159\/000164799","type":"journal-article","created":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T08:25:14Z","timestamp":1224836714000},"page":"44-52","source":"Crossref","is-referenced-by-count":0,"title":["Mineralocorticoids Restore Quiescent Morphology and Reduce VEGF Receptor Expression in Inflamed Choroidal Endothelial Cells in vitro"],"prefix":"10.1159","volume":"41","author":[{"given":"Melinda","family":"Fitzgerald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Evill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Banz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rodger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1350-9462%2802%2900043-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jss.2004.05.007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118816"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.34.22128"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.48.5.1145"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M310678200"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2005.076190"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0163-7258%2899%2900038-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2003.05.037"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00417-005-0052-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10384-003-0053-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.05-0772"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.2001.4275"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006%2Fmvre.1994.1050"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2005.072108"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Flabinvest.3700251"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4652%28199708%29172%3A2%3C171%3A%3AAID-JCP4%3E3.0.CO%3B2-L"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00674.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2005-1318"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/164799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/164799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:42:49Z","timestamp":1745455369000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000164799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,22]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000164799","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2008,10,22]]}}}