{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:55:07Z","timestamp":1776995707895,"version":"3.51.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background\/Aims:<\/i> Primary antineutrophil cytoplasmic antibodies (ANCA)-associated systemic vasculitis (AASV) used to have poor prognosis, and renal involvement is its most common manifestation. Few studies have been published focusing on AASV patients with poor prognosis. <i>Methods:<\/i> From 1997 to 2006, 101 patients with ANCA-associated renal vasculitis (70 microscopic polyangiitis, MPA; 14 Wegener\u2019s granulomatosis, WG; 3 Churg-Strauss syndrome, CSS; 14 renal limited vasculitis, RLV) were diagnosed in Shanghai Ruijin Hospital and 26 deaths were recorded among them. Patients\u2019 data were retrospectively analyzed. <i>Results:<\/i> Patients with WG, MPA and RLV made up for 23.1% (6\/26), 65.4% (17\/26) and 11.5% (3\/26) of all deaths. No deaths were observed among CSS patients. Infection alone accounted for 13 deaths. Infection together with pulmonary involvement of active vasculitis accounted for 3. Organ-specific involvement of active vasculitis alone caused 8 deaths. Others died of acute myocardial infarction or gastric carcinoma. Compared with patients who survived, nonsurvivors had more severe renal insufficiency and older age (p < 0.01). There was no significant difference regarding clinical presentation at diagnosis and cause of death between patients who survived first remission-induction treatment and those who did not. Infection remained the major cause of death. <i>Conclusion:<\/i> Infection is the major cause of death in patients with ANCA-associated renal vasculitis, and treatment response might not correlate to severity of disease in patients with poor prognosis. Rational use of immunosuppressants could improve the prognosis.<\/jats:p>","DOI":"10.1159\/000165117","type":"journal-article","created":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T08:25:14Z","timestamp":1224836714000},"page":"343-349","source":"Crossref","is-referenced-by-count":35,"title":["Analyzing Fatal Cases of Chinese Patients with Primary Antineutrophil Cytoplasmic Antibodies-Associated Renal Vasculitis: A 10-Year Retrospective Study"],"prefix":"10.1159","volume":"31","author":[{"given":"Yong-Xi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Jin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Nong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Xia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Yan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780370206"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2806%2969114-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2803%2900025-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2Fkeh522"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780330807"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780330806"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000180580"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005080882"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2FBOR.0b013e3280119842"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000085854"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F15.5.611"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00769.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh161"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005080870"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2006.01.026"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00005792-199901000-00003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.04.018"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.298.6.655"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F01.md.0000180793.80212.17"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/165117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/165117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:45:54Z","timestamp":1745455554000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000165117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000165117","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}