{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:19:06Z","timestamp":1763036346905,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T00:00:00Z","timestamp":1224547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T00:00:00Z","timestamp":1224547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Giant condyloma acuminatum (GCA; Buschke-L\u00f6wenstein tumor) is a human-papillomavirus-induced cauliflower-like tumor of the genitoanal region. It is characterized by its size, capability of local infiltration and high recurrence rate. We report on a 50-year-old patient presenting with a maximum finding of GCA with deep infiltration into the adductor and perineal musculature, the scrotum, the penis and the pararectum. After performing a temporary loop colostomy, the tumor was removed by wide radical excision following plastic reconstruction with a myocutaneous gracilis flap. During a follow-up period of more than 5 years, no recurrence developed. Many treatment strategies (e.g. chemotherapy, radiation) have been published in the literature. Most authors recommend the radical surgical excision, allowing a complete histological examination and assessment of tumor-free resection margins. Despite the benign histological pattern of GCA in most cases, transformations into verrucous carcinoma and squamous-cell carcinoma have been described. In our case, the GCA seems to represent a continuum between normal condyloma acuminatum and an initial verrucous carcinoma.<\/jats:p>","DOI":"10.1159\/000165359","type":"journal-article","created":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T12:58:54Z","timestamp":1224507534000},"page":"56-59","source":"Crossref","is-referenced-by-count":36,"title":["Successful Surgical Management of Giant Condyloma Acuminatum (Buschke-L\u00f6wenstein Tumor) in the Genitoanal Region: A Case Report and Evaluation of Current Therapies"],"prefix":"10.1159","volume":"218","author":[{"given":"P.","family":"Gholam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Enk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Hartschuh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01728480"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0190-9622%2895%2990177-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02234473"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00186418"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02052606"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000106589"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02237065"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1479-666X%2806%2980114-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fjso.20422"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FPL00012104"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199405000-00010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02626784"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1288%2F00005537-199504000-00011"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/165359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/165359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:48:44Z","timestamp":1745455724000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000165359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,21]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000165359","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2008,10,21]]}}}