{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:48:40Z","timestamp":1770432520075,"version":"3.49.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T00:00:00Z","timestamp":1225065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T00:00:00Z","timestamp":1225065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Early diagnosis of proximal tubular lesions can be achieved by detecting abnormal levels of low molecular weight proteins in urine. &lt;i&gt;Material and Methods:&lt;\/i&gt; 100 cases of glomerulopathies were retrospectively studied to establish the profile of urinary levels of retinol-binding protein (urRBP) and their correlation with histological markers of tubulointerstitial lesions in renal biopsies. The histological study included staining with picrosirius red. &lt;i&gt;Results:&lt;\/i&gt; Nonproliferative glomerulopathies, male sex, white race and young adults were predominant. The chance of abnormal urRBP occurring was higher among patients with a predominant proliferative component, baseline serum creatinine &gt;1.2 mg\/dl (p = 0.008), creatinine clearance &lt;70 ml\/min (p = 0.006), and severe interstitial fibrosis (p = 0.042). In multivariate analysis, only serum creatinine and creatinine clearance were independently associated to urRBP, and only urRBP was a time-independent prognostic factor for survival without renal failure (risk of renal failure: 9\u00d7). &lt;i&gt;Conclusion:&lt;\/i&gt; Our study suggests that urRBP determination is prognostically relevant in the progression of glomerulopathies; on the other hand, the evaluated morphometric markers correlated poorly with the clinical outcome of these patients. Consequently, urRBP determination, as a functional marker of tubulointerstitial damage, was more appropriate for determining the prognosis of glomerular diseases than the morphometric analysis of renal biopsies.<\/jats:p>","DOI":"10.1159\/000166992","type":"journal-article","created":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T15:47:05Z","timestamp":1225122425000},"page":"c164-c171","source":"Crossref","is-referenced-by-count":7,"title":["Relative Contribution of Morphometric and Functional Indicators of Tubulointerstitial Lesion to Glomerular Diseases Prognosis"],"prefix":"10.1159","volume":"110","author":[{"given":"Rogerio","family":"Barbosa de Deus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"de Paulo Castro Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna","family":"Mastroianni Kirsztajn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01747747"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000167514"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000181679"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0046-8177%2870%2980061-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2868%2990589-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2169%2Finternalmedicine.43.9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2362.1971.tb00555.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0009-8981%2882%2990356-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000045727"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000054730"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000066143.02832.5E"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0009-8981%2888%2990293-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl237"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/166992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/166992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:25:30Z","timestamp":1745450730000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000166992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,27]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000166992","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,27]]}}}