{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:03:53Z","timestamp":1789376633333,"version":"build-2803163510"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,11,6]],"date-time":"2008-11-06T00:00:00Z","timestamp":1225929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,11,6]],"date-time":"2008-11-06T00:00:00Z","timestamp":1225929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>This study aimed to develop a new experimental model of liver cirrhosis in swine by using carbon tetrachloride (CCl&lt;sub&gt;4&lt;\/sub&gt;) and ethanol. Liver cirrhosis was induced by intraperitoneal injection of CCl&lt;sub&gt;4&lt;\/sub&gt; twice a week for 9 weeks. Maize flour was the only food provided and the animals drunk a 5% alcohol-water mixture. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, bilirubin and portal venous pressure (PVP) levels were determined throughout CCl&lt;sub&gt;4&lt;\/sub&gt; treatment. The animals were sacrificed under general anesthesia at week 9 and liver samples were collected for histological analysis. 83.3% of the swine had liver cirrhosis and 33.3% had died. There was no change of body weight during the course of the experiment (p &gt; 0.05). The AST and ALT levels increased significantly in the early stage of the study but had a trend to decrease during the late phase. The level of bilirubin increased greatly and albumin decreased during the whole experiment (p &lt; 0.05). PVP levels decreased in the early stage in CCl&lt;sub&gt;4&lt;\/sub&gt;-treated swine, but increased significantly at the late phase. In conclusion, this study was successful in producing liver cirrhosis and offers an ideal experimental model for observing surgical therapeutic efficacy.<\/jats:p>","DOI":"10.1159\/000167855","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T05:16:19Z","timestamp":1226034979000},"page":"35-39","source":"Crossref","is-referenced-by-count":21,"title":["Development of a New Animal Model of Liver Cirrhosis in Swine"],"prefix":"10.1159","volume":"42","author":[{"given":"J.-J.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.-K.","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-L.","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.-F.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.-Q.","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-Y.","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2960383-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Flt.20137"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000128709"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1700420104"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F10408447309082019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-291X%2880%2990540-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1711560106"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01261725"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2008-1040457"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.1840090326"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2007.03.110"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.1840180429"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1292%2Fjvms.67.403"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3736%2Fjcim20060312"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1681.2000.03381.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cld.2006.08.005"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/167855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/167855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:34:58Z","timestamp":1745436898000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000167855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,6]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000167855","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,6]]}}}