{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:49:24Z","timestamp":1745470164726,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background\/Aims:<\/i> The aim of the study was to investigate gastric emptying profiles in patients with postprandial distress syndrome (PDS) as a means to understand relationships between gastric emptying and dyspepsia. <i>Methods:<\/i> Gastric emptying times were measured using a <sup>13<\/sup>C breath test. In addition to comparisons of <sup>13<\/sup>C half excretion times (t 1\/2 ex) between patients with PDS and healthy subjects, gastric emptying (%dose\/h) curves were analyzed using a multipeak curve-fitting technique, and fitted curves were differentiated to measure the slope of curves for each time point. <i>Results:<\/i> (1) During the early postcibal period, the slope of %dose\/h curves in 27% of patients with PDS was larger than the average slope derived from healthy subjects. The t 1\/2 ex was also higher in these patients relative to healthy subjects. (2) During the midpostcibal period, the slope of %dose\/h curves in 36% of PDS patients was larger than the average slope derived from healthy subjects. There was a trend toward lower t 1\/2 ex values for these patients relative to control subjects. (3) When t 1\/2 ex was calculated overall, however, there was no significant difference between healthy subjects and patients with PDS. <i>Conclusion:<\/i> Our findings document abnormal gastric outflow in patients with PDS. In some patients, there appears to be a significant correspondence between PDS-related dyspepsia and accelerated gastric emptying in the early postcibal period, whereas other patients showed a similar correspondence between dyspepsia and impaired inhibitory gastric emptying regulation in the midpostcibal period.<\/jats:p>","DOI":"10.1159\/000167861","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T08:53:22Z","timestamp":1232441602000},"page":"13-18","source":"Crossref","is-referenced-by-count":18,"title":["Investigation of Gastric Emptying Disorders in Patients with Functional Dyspepsia Reveals Impaired Inhibitory Gastric Emptying Regulation in the Early Postcibal Period"],"prefix":"10.1159","volume":"79","author":[{"given":"Hiroaki","family":"Zai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyasu","family":"Kusano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.13.10.768"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109%2F00365528509088842"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-198608000-00008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109%2F00365529109109534"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2000.00868.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1018881419010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02300385"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1248%2Fbpb.24.70"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0169-2607%2885%2990084-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1541-0420.2007.00758.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11938-000-0042-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.51.2.219"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2898%2970012-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2005.085365"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080%2F00365520252903206"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.08.062"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.11.059"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/167861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/167861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:35:00Z","timestamp":1745451300000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000167861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":17,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000167861","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2009]]}}}