{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:54:40Z","timestamp":1777769680545,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,10,29]],"date-time":"2008-10-29T00:00:00Z","timestamp":1225238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,10,29]],"date-time":"2008-10-29T00:00:00Z","timestamp":1225238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>Myocardial oxygen consumption (MyO&lt;sub&gt;2&lt;\/sub&gt;) was measured in intact, anesthetized dogs prior to and during an acute elevation of arterial free fatty acids (FFA). FFA were elevated by the infusion of a lipid emulsion (\u2018Intralipid\u2019) coupled with heparin to intensify lipolysis. Intralipid infusion prior to heparin (n = 7) caused a small increase in FFA (352 \u00b1 41\u2013666 \u00b1 67 \u00b5Eq\/l) without significant change in either MyO&lt;sub&gt;2&lt;\/sub&gt; or hemodynamics. Following heparin, arterial FFA rose from a base line, preheparin level of 649 \u00b1 50\u20131,925 \u00b1 186 \u00b5Eq\/l at 10 min, 1,988 \u00b1 247 \u00b5Eq\/l at 20 min, and 1,750 \u00b1 221 \u00b5.\/Eq\/l at 30 min. Hemodynamics were essentially stable throughout the study. No significant change was observed in either MyO&lt;sub&gt;2&lt;\/sub&gt; or mean coronary blood flow, while myocardial oxygen extraction showed a small but significant increase at 10 and 30 min. An acute elevation of arterial FFA within the physiologic range does not significantly affect myocardial oxygen consumption in the intact, closed-chest anesthetized dog.<\/jats:p>","DOI":"10.1159\/000169637","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T11:35:40Z","timestamp":1225452940000},"page":"220-228","source":"Crossref","is-referenced-by-count":8,"title":["Failure of Free Fatty Acids to Influence Myocardial Oxygen Consumption in the Intact, Anesthetized Dog"],"prefix":"10.1159","author":[{"given":"Albert S.","family":"Most","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton H.","family":"Lipsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Szydlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,10,29]]},"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/169637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000169637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:21:18Z","timestamp":1777479678000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000169637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000169637","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,29]]}}}