{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:13:43Z","timestamp":1789384423014,"version":"build-2803163510"},"reference-count":29,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T00:00:00Z","timestamp":1226448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T00:00:00Z","timestamp":1226448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background&lt;\/i&gt;&lt;i&gt;and Aims:&lt;\/i&gt; Calcium-containing phosphate binders have been shown to increase the progression of vascular calcification in hemodialysis patients. This is a prospective study that compares the effects of calcium acetate and sevelamer on coronary calcification (CAC) and bone histology. &lt;i&gt;Methods:&lt;\/i&gt; 101 hemodialysis patients were randomized for each phosphate binder and submitted to multislice coronary tomographies and bone biopsies at entry and 12 months. &lt;i&gt;Results:&lt;\/i&gt; The 71 patients who concluded the study had similar baseline characteristics. On follow-up, the sevelamer group had higher levels of intact parathyroid hormone (498 \u00b1 352 vs. 326 \u00b1 236 pg\/ml, p = 0.017), bone alkaline phosphatase (38 \u00b1 24 vs. 28 \u00b1 15 U\/l, p = 0.03) and deoxypyridinoline (135 \u00b1 107 vs. 89 \u00b1 71 nmol\/l, p = 0.03) and lower LDL cholesterol (74 \u00b1 21 vs. 91 \u00b1 28 mg\/dl, p = 0.015). Phosphorus (5.8 \u00b1 1.0 vs. 6 \u00b1 1.0 mg\/dl, p = 0.47) and calcium (1.27 \u00b1 0.07 vs. 1.23 \u00b1 0.08 mmol\/l, p = 0.68) levels did not differ between groups. CAC progression (35 vs. 24%, p = 0.94) and bone histological diagnosis at baseline and 12 months were similar in both groups. Patients of the sevelamer group with a high turnover at baseline had an increase in bone resorption (eroded surface, ES\/BS = 9.0 \u00b1 5.9 vs. 13.1 \u00b1 9.5%, p = 0.05), whereas patients of both groups with low turnover at baseline had an improvement in bone formation rate (BFR\/BS = 0.015 \u00b1 0.016 vs. 0.062 \u00b1 0.078, p = 0.003 for calcium and 0.017 \u00b1 0.016 vs. 0.071 \u00b1 0.084 \u03bcm&lt;sup&gt;3&lt;\/sup&gt;\/\u03bcm&lt;sup&gt;2&lt;\/sup&gt;\/day, p = 0.010 for sevelamer). &lt;i&gt;Conclusions:&lt;\/i&gt; There was no difference in CAC progression or changes in bone remodeling between the calcium and the sevelamer groups.<\/jats:p>","DOI":"10.1159\/000170783","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T13:17:04Z","timestamp":1226495824000},"page":"c273-c283","source":"Crossref","is-referenced-by-count":124,"title":["Phosphate Binder Impact on Bone Remodeling and Coronary Calcification \u2013 Results from the BRiC Study"],"prefix":"10.1159","volume":"110","author":[{"given":"Daniela Veit","family":"Barreto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fellype de Carvalho","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alu\u00edzio Barbosa","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Cuppari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Antonio","family":"Draibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida","family":"Dalboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria 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