{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:29:28Z","timestamp":1790029768631,"version":"4.0.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T00:00:00Z","timestamp":1226534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T00:00:00Z","timestamp":1226534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>A novel &lt;i&gt;TECTA &lt;\/i&gt;mutation (c.5331G&gt;A) was identified affecting \u03b1-tectorin just N-terminally of the zona pellucida domain in a Dutch family with nonsyndromic autosomal dominant sensorineural hearing impairment. The present mutation is clearly associated with a flat-threshold type of hearing impairment. Intriguingly, our results demonstrated that the present &lt;i&gt;TECTA&lt;\/i&gt; mutation had a significant protective effect against presbyacusis. Substantial protection against presbyacusis is a novel finding in a family with autosomal dominant hearing impairment.<\/jats:p>","DOI":"10.1159\/000171477","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T12:50:46Z","timestamp":1226667046000},"page":"153-162","source":"Crossref","is-referenced-by-count":13,"title":["Flat Threshold and Mid-Frequency Hearing Impairment in a Dutch DFNA8\/12 Family with a Novel Mutation in &lt;i&gt;TECTA&lt;\/i&gt;"],"prefix":"10.1159","volume":"14","author":[{"given":"A.R.","family":"de Heer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Pauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.L.M.","family":"Huygen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.W.J.","family":"Collin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.W.R.J.","family":"Cremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejhg.5200273"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004390051091"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086%2F514892"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2273.2001.00477.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000015086"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2273.2000.00327.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.272.13.8791"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0896-6273%2800%2900102-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109%2F00016486009123147"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080%2F16513860301713"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2F70516"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0004.2007.00828.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00439-002-0836-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.38.5.e13"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.40.11.832"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.134.3.294"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000080347"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10162-006-0033-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10162-006-0060-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1258%2F0022215054352216"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.2003.010702"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0598-60"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/171477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/171477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:10:23Z","timestamp":1745453423000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000171477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,13]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000171477","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,13]]}}}