{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:51:57Z","timestamp":1745470317216,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[1989]]},"abstract":"<jats:p>N-phenylanthranilic acid (N-PAA; 4mmol\/kg\/day p.o.) causes a diffuse renal papillary necrosis and a polyuria in 7 days. A single dose of &lt;sup&gt;3&lt;\/sup&gt;H-N-PAA was widely distributed with second-order elimination kinetics, t&lt;sub&gt;\u00bd&lt;\/sub&gt; \u00b1 50 h for stomach, heart, kidney, and bladder and t&lt;sub&gt;\u00bd&lt;\/sub&gt; \u226790 h for liver, spleen, muscle and lung. The estimated plasma t&lt;sub&gt;\u00bd&lt;\/sub&gt; = 10.2 h, and over 75% was excreted via urine in 36h and 13% via faeces in 72 h. In chronically cannulated animals 29% of N-PAA-derived material was in bile and 24% in urine at 36 h, which suggests enterohepatic circulation. Bile and urine contained several metabolites but no parent compound. Multiple doses for 8 and 16 days increased urinary N-PAA excretion to 90% in 36 h, but faecal contents decreased to 6-8% in 72 h and plasma t&lt;sub&gt;1\/2&lt;\/sub&gt; to \u2264 7.5h.<\/jats:p>","DOI":"10.1159\/000173219","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T10:48:13Z","timestamp":1226314093000},"page":"406-412","source":"Crossref","is-referenced-by-count":0,"title":["The Kinetics of Papillotoxic Doses of &lt;sup&gt;3&lt;\/sup&gt;H-N-Phenylanthranilic Acid in Rats"],"prefix":"10.1159","volume":"12","author":[{"given":"Alan","family":"Whittingham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia","family":"Delacruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil J.","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amulfo","family":"Albores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ijomah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Bach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,7]]},"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/173219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/173219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:30:48Z","timestamp":1745454648000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000173219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989]]},"references-count":0,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000173219","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[1989]]}}}