{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:00:01Z","timestamp":1777770001406,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T00:00:00Z","timestamp":1226016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T00:00:00Z","timestamp":1226016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>The O&lt;sub&gt;2&lt;\/sub&gt; uptake response to symptom-limited progressive bicycle exercise that was performed serially before and up to 1 year after uncomplicated isolated aortic valve replacement (AVR) was evaluated in 37 patients. Before surgery, an unusually rapid exercise O&lt;sub&gt;2&lt;\/sub&gt; uptake response was seen in about half the patients, while the AVR appeared to result in a change in O&lt;sub&gt;2&lt;\/sub&gt; uptake kinetics to within normal limits in the majority of the patients within the first 3 postoperative months. The inappropriate O&lt;sub&gt;2&lt;\/sub&gt; uptake response was found to be associated with more significant limitation in exercise tolerance, and it appeared to be mediated not only by a pronounced exercise heart rate response but, probably, also by an exaggerated arteriovenous O&lt;sub&gt;2&lt;\/sub&gt; difference. These findings suggest that peripheral vascular responses in patients with chronic aortic valve disease may play a major role in the different O&lt;sub&gt;2&lt;\/sub&gt; uptake responses to progressive bicycle exercise. The physiological significance of O&lt;sub&gt;2&lt;\/sub&gt; kinetics during exercise, however, requires further study.<\/jats:p>","DOI":"10.1159\/000173577","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T05:48:13Z","timestamp":1226296093000},"page":"110-118","source":"Crossref","is-referenced-by-count":2,"title":["Response to Progressive Bicycle Exercise before and following Aortic Valve Replacement"],"prefix":"10.1159","author":[{"given":"Kari O.","family":"Niemel\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku J.","family":"Ik\u00e4heimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku L.","family":"Linnaluoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha T.","family":"Takkunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,7]]},"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000173577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:27:00Z","timestamp":1777480020000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000173577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000173577","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,7]]}}}