{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:54:18Z","timestamp":1779177258543,"version":"3.51.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,11,27]],"date-time":"2008-11-27T00:00:00Z","timestamp":1227744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,11,27]],"date-time":"2008-11-27T00:00:00Z","timestamp":1227744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Bisphosphonates have been reported to decrease fractures related to osteogenesis imperfecta (OI). We assessed the efficacy and long-term safety of pamidronate therapy in patients with moderate-to-severe OI. &lt;i&gt;Methods:&lt;\/i&gt; We conducted an open-label uncontrolled study in 14 boys and 13 girls whose mean age was 6.8 years at baseline. Intravenous pamidronate, 1 mg\/kg\/day, was given for 3 consecutive days every 4 months for 2\u20136 years, with physical therapy and orthopedic surgery as appropriate. Mobility score, fracture rate, height, bone mineral density (BMD) and bone healing were evaluated throughout follow-up. &lt;i&gt;Results:&lt;\/i&gt; In 24 (89%) patients, the fracture rate decreased to \u22642\/year and\/or the mobility score improved. The remaining 3 (11%) patients continued to experience more than 2 fractures per year with mobility scores &lt;2 despite significant BMD gains. Delayed radiographic fracture healing (&gt;6 months) occurred in 8 (29.6%) patients; their BMD gains, baseline age and treatment duration were not significantly different from those in the other patients. Tolerance was good. &lt;i&gt;Conclusion:&lt;\/i&gt; Pamidronate with physiotherapy and orthopedic management improved outcomes without delaying fracture healing in 19 (70%) of 27 patients. Delayed fracture healing occurred in 8\/27 patients. Pamidronate should be reserved for severe OI with multiple fractures and\/or flattened vertebras.<\/jats:p>","DOI":"10.1159\/000173740","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T14:20:02Z","timestamp":1227968402000},"page":"38-44","source":"Crossref","is-referenced-by-count":12,"title":["Pamidronate Treatment of Children with Moderate-to-Severe Osteogenesis Imperfecta: A Note of Caution"],"prefix":"10.1159","volume":"71","author":[{"given":"M.","family":"Alharbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Finidori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Souberbielle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Guillou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gaubicher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Le Merrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Polak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2916051-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00223-001-1055-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jbspin.2004.08.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1359%2FJBMR.040303"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199810013391402"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bone.2003.11.019"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2003.18.4.610"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00247-004-1393-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-2036"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.10.041"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.86.5.356"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.111.3.573"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bone.2004.07.003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI116872"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F01.bpo.0000152940.10487.c9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1359%2FJBMR.040814"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177%2F000992289903801201"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.70.4.331"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080%2F08035259950168135"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.5.1846"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.111.5.1030"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021371"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200215952"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa023110"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bone.2004.03.008"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.joms.2004.02.004"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMc062792"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-2413"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/173740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/173740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:37:55Z","timestamp":1745455075000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000173740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,27]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000173740","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,27]]}}}