{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:06:43Z","timestamp":1777770403928,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T00:00:00Z","timestamp":1226448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T00:00:00Z","timestamp":1226448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>This study was designed to assess the sensitivity of the monocationic 99mTc-hexakis-2-methoxy, 2-methylpropylisonitrile (99mTc-sestamibi) as compared to 201T1 in the detection of regional myocardial blood flow deficits in dogs with different degrees of stenosis with or without dipyridamole. Regional myocardial distribution of 99mTc-sestamibi and 201T1 was determined in mongrel dogs under different levels of left arterial descending coronary artery (LAD) stenosis (30\u201345, 60\u201370 and 100% flow reduction) as monitored with electromagnetic flow probes and radiolabeled microspheres. Both 99mTc-sestamibi and 201T1 distribute in direct proportion to blood flow at all levels of stenosis (r2 = 0.90\u20130.99). Quantitatively, both tracers underestimate the resting flow stenosis. The regional myocardial distribution for both 99mTc and 20lTl was also determined in subcritically stenosed mongrel dogs. This was produced by placing a balloon cuff around the LAD, infusing dipyridamole to peak hyperemic flow and immediately stenosing the LAD to basal flow. Stenosed to normal zone flow ratios were 0.68 \u00b1 0.01 compared to 99mTc and 201T1 ratios of 0.73 \u00b1 0.04 and 0.80 \u00b1 0.05, respectively. These data suggest that 99mTc is at least as sensitive as 201T1 in the detection of different degrees of critical and subcritical coronary artery stenosis.<\/jats:p>","DOI":"10.1159\/000174871","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T07:50:46Z","timestamp":1226649046000},"page":"135-145","source":"Crossref","is-referenced-by-count":1,"title":["Detection Sensitivity of Coronary Artery Stenosis by\n                    <sup>99m<\/sup>\n                    Tc-Sestamibi and\n                    <sup>201<\/sup>\n                    T1 in Canine Models of Partial and Subcritical Stenosis"],"prefix":"10.1159","author":[{"given":"S.A.","family":"Mousa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Cooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,12]]},"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000174871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:34:00Z","timestamp":1777480440000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000174871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000174871","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,12]]}}}